基于电子舌、GC-IMS技术和人工感官评价对小儿感冒颗粒的气味分析及口感改善研究  

Odor Analysis and Taste Improvement of Xiao′er Ganmao Granules Based on Electronic Tongue,GC-IMS Technology,and Artificial Sensory Evaluation

作　　者：万顺 谭润泽 何倜 何金芳 郭静 白璐 龚云 张鹏 杨秀伟[3] 凌勇根 王炜[1] WAN Shun;TAN Run-ze;HE Ti;HE Jin-fang;GUO Jing;BAI Lu;GONG Yun;ZHANG Peng;YANG Xiu-wei;LING Yong-gen;WANG Wei(Hunan University of Chinese Medicine,Changsha 410208,China;Zhuzhou Qianjin Pharmaceutical Co.,Ltd.,Zhuzhou 412007,China;State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences,Peking University,Beijing 100191,China)

机构地区：[1]湖南中医药大学,湖南长沙410208 [2]株洲千金药业股份有限公司,湖南株洲412007 [3]北京大学药学院天然药物及仿生药物全国重点实验室,北京100191

出　　处：《中国现代中药》2024年第9期1586-1595,共10页Modern Chinese Medicine

摘　　要：目的:改善小儿感冒颗粒的口感,提高患者用药依从性。方法:采用气相色谱-离子迁移谱法(GCIMS)分析小儿感冒颗粒气味并确定气味来源,采用电子舌分析评价热浸温度、加水量、矫味剂、贮存期等参数对小儿感冒颗粒口感的影响,并结合排序+评分法(ISEM)综合评价矫味剂对小儿感冒颗粒的矫味效果。结果:通过GC-IMS分析在小儿感冒颗粒中共检测出57个挥发性物质,气味主要来自挥发油、挥发油滤液和热浸液中的有机酸类及部分醛类;电子舌分析结果表明,生产工艺中不同参数各中间产品口感上的差别并不影响颗粒的最终口感,结合ISEM评价体系进行人工感官评价,最终得出添加2‰氯化钠矫味可以明显改善小儿感冒颗粒的口感,其口感会随贮存期发生变化。结论:通过GC-IMS分析、电子舌智能感官评定与人工口尝评价相结合的方法可以科学合理地筛选出小儿感冒颗粒的最佳矫味剂组合,显著地改善其口感,优化制剂配方。Objective:To improve the taste of Xiao′er Ganmao Granules and improve the medication compliance of patients.Methods:In this experiment,the gas chromatography-ion mobility spectroscopy(GC-IMS)technology was used to analyze the odor of Xiao′er Ganmao Granules and to determine its source,and electronic tongue was used to evaluate the influence of production process parameters such as hot dipping temperature,water addition,flavoring agent,and storage period on the taste of Xiao′er Ganmao Granules.Moreover,the integrated score evaluation method(ISEM)was used to comprehensively evaluate the effect of the flavoring agent on Xiao′er Ganmao Granules.Results:From a total of 57 volatile substances detected in Xiao′er Ganmao Granules through GC-IMS analysis,The odor mainly came from the organic acids and some aldehydes in the volatile oil,volatile oil filtrate,and hot dipping solution.From the analysis of the electronic tongue,the difference in the taste of intermediate products under different parameters shows no effect on the final Granules.Using artificial sensory evaluation combined with ISEM,this study found that the addition of 2‰sodium chloride can significantly improve the taste of Xiao′er Ganmao Granules,and it will change with the storage period.Conclusion:This study provides great references for improving the taste of Xiao′er Ganmao Granules by giving the above result.

关 键 词：电子舌 小儿感冒颗粒 口感 气味 

分 类 号：R286[医药卫生—中药学]