Microvascular alterations of the ocular surface and retina in connective tissue disease-related interstitial lung disease  

作　　者：Li-Ming Chen Min Kang Jun-Yi Wang San-Hua Xu Cheng Chen Hong Wei Qian Ling Liang-Qi He Jie Zou Yi-Xin Wang Xu Chen Ping Ying Hui Huang Yi Shao Rui Wu 

机构地区：[1]Department of Rheumatology,the First Affiliated Hospital of Nanchang University,Nanchang 330006,Jiangxi Province,China [2]Department of Ophthalmology,the First Affiliated Hospital of Nanchang University,Nanchang 330006,Jiangxi Province,China [3]The First School of Clinical Medicine of Nanchang University,Jiangxi Medical College of Nanchang University,Nanchang 330000,Jiangxi Province,China [4]School of Optometry and Vision Science,Cardiff University,Cardiff,CF244HQ,Wales,UK [5]Ophthalmology Centre of Maastricht University,Maastricht 6200MS,Limburg Provincie,Netherlands [6]Department of Ophthalmology,Eye&ENT Hospital of Fudan University,Shanghai 200030,China

出　　处：《International Journal of Ophthalmology(English edition)》2024年第10期1869-1879,共11页国际眼科杂志（英文版）

基　　金：Supported by National Natural Science Foundation of China(No.82160195);Key R&D Program of Jiangxi Province(No.20223BBH80014);General Science and Technology Program of the Department of Traditional Chinese Medicine,Jiangxi Provincial Health Commission(No.2017A241).

摘　　要：AIM:To examine the disparities in macular retinal vascular density between individuals with connective tissue disease-related interstitial lung disease(CTD-ILD)and healthy controls(HCs)by optical coherence tomography angiography(OCTA)and to investigate the changes in microvascular density in abnormal eyes.METHODS:For a retrospective case-control study,a total of 16 patients(32 eyes)diagnosed with CTD-ILD were selected as the ILD group.The 16 healthy volunteers with 32 eyes,matched in terms of age and sex with the patients,were recruited as control group.The macular retina’s superficial retinal layer(SRL)and deep retinal layer(DRL)were examined and scanned using OCTA in each individual eye.The densities of retinal microvascular(MIR),macrovascular(MAR),and total microvascular(TMI)were calculated and compared.Changes in retinal vascular density in the macular region were analyzed using three different segmentation methods:central annuli segmentation method(C1-C6),hemispheric segmentation method[uperior right(SR),superior left(SL),inferior left(IL),and inferior right(IR)],and Early Treatment Diabetic Retinopathy Study(ETDRS)methods[superior(S),inferior(I),left(L),and right(R)].The data were analyzed using Version 9.0 of GraphPad prism and Pearson analysis.RESULTS:The OCTA data demonstrated a statistically significant difference(P<0.05)in macular retinal microvessel density between the two groups.Specifically,in the SRL and DRL analyses,the ILD group exhibited significantly lower surface density of MIR and TMI compared to the HCs group(P<0.05).Furthermore,using the hemispheric segmentation method,the ILD group showed notable reductions in SL,SR,and IL in the superficial retina(P<0.05),as well as marked decreases in SL and IR in the deep retina(P<0.05).Similarly,when employing the ETDRS method,the ILD group displayed substantial drops in superficial retinal S and I(P<0.05),along with notable reductions in deep retinal L,I,and R(P<0.05).In the central annuli segmentation method,the ILD group exhibited a significant de

关 键 词：connective tissue disease‑related interstitial lung disease optical coherence tomography angiography microvessel density ocular surface RETINA 

分 类 号：R774.1[医药卫生—眼科]