蜂胶酚类化合物缓解高脂饮食诱导非酒精性脂肪性肝病的作用效果及机制研究进展  

Research Progress in the Effect and Mechanism of Propolis Polyphenols in Alleviating High Fat Diet-Induced Non-alcoholic Fatty Liver Disease

作　　者：鲍佳益 于心雨 祝梅斐 卢媛媛[1] 李珊珊 胡福良[1] BAO Jiayi;YU Xinyu;ZHU Meifei;LU Yuanyuan;LI Shanshan;HU Fuliang(Key Laboratory of Silkworm and Bee Resource Utilization and Innovation of Zhejiang Province,College of Animal Sciences,Zhejiang University,Hangzhou 310058,China)

机构地区：[1]浙江大学动物科学学院,浙江省蚕蜂资源利用与创新研究重点实验室,浙江杭州310058

出　　处：《食品科学》2024年第19期332-341,共10页Food Science

基　　金：现代农业产业技术体系建设专项(CARS-44)。

摘　　要：随着饮食习惯和生活质量的改变,非酒精性脂肪性肝病的发病率逐年升高,已成为全球主要公共卫生问题之一。由于疾病的复杂性,尚未批准用于治疗的药物。蜂胶是一种天然胶状产物,具有广泛的药理活性,在临床上可用于治疗冠心病、糖尿病、高血压、高脂血症等疾病。研究表明,蜂胶及其酚类化合物具有降低脂肪、抗氧化、抗炎等药理活性,在缓解非酒精性脂肪性肝病方面有良好的应用前景。因此,本文对近年来蜂胶及其酚类化合物缓解非酒精性脂肪性肝病的研究进行综述,以期为蜂胶缓解非酒精性脂肪性肝病的研究提供理论参考。As dietary habits and the quality of life change,the incidence of non-alcoholic fatty liver disease has increased year by year and has become one of the major public health problems in the world.Due to the complexity of the disease,no drug has been approved for its treatment.Propolis is a natural gelatinous product with extensive pharmacological activities,which can be used in clinical treatment of coronary heart disease,diabetes,hypertension,hyperlipidemia and other diseases.Studies have shown that propolis and its phenolic compounds have pharmacological activities such as hypolipidemic,antioxidant and anti-inflammatory effects,making them promising in alleviating non-alcoholic fatty liver disease.Therefore,this article reviews recent studies on propolis and its phenolic compounds in alleviating non-alcoholic fatty liver disease in order to provide a theoretical reference for research on the alleviative effect of propolis on non-alcoholic fatty liver disease.

关 键 词：蜂胶 酚类化合物 非酒精性脂肪性肝病 机制 

分 类 号：S896.6[农业科学—特种经济动物饲养]