脑铁沉积与脑小血管病  

Cerebral iron deposition and cerebral small vascular disease

作　　者：江俊莹 陈雪梅 Jiang Junying;Chen Xuemei(Department of Neurology,Jiangning Hospital Affiliated to Nanjing Medical University,Nanjing 211100,China)

机构地区：[1]南京医科大学附属江宁医院神经内科,南京211100

出　　处：《国际脑血管病杂志》2024年第5期386-391,共6页International Journal of Cerebrovascular Diseases

基　　金：江苏省卫健委课题(M2022009);南京市卫生科技发展专项资金资助项目(ZKX23061、YKK20203);江宁区科技惠民计划项目(2023068S)。

摘　　要：铁代谢是人体的重要生理学过程。当脑铁代谢失衡引起铁超载时,会导致脑铁沉积,使脑细胞发生氧化应激损伤。近年来的研究显示,脑铁沉积与脑小血管病密切相关。文章对脑铁沉积与脑小血管病的最新研究进展进行了综述,以期为脑小血管病的诊治提供新的思路。Iron metabolism is an important physiological process in the human body.When the imbalance of brain iron metabolism causes iron overload,it can lead to brain iron deposition,causing oxidative stress damage to brain cells.Recent studies have shown that brain iron deposition is closely associated with cerebral small vessel disease(CSVD).This article reviews the latest research progress on brain iron deposition and CSVD,aiming to provide new ideas for the diagnosis and treatment of CSVD.

关 键 词：脑小血管疾病 铁 铁代谢障碍 白质 脑出血 CADASIL 认知障碍 磁共振成像 

分 类 号：R743[医药卫生—神经病学与精神病学]