Deciphering disease through glycan codes:leveraging lectin microarrays for clinical insights  

作　　者：Hangzhou Yang Zihan Lin Bo Wu Jun Xu Sheng-Ce Tao Shumin Zhou 

机构地区：[1]Department of General Surgery,Shanghai Jiao Tong University Affiliated Sixth People’s Hospital,Shanghai 200233,China [2]Institute of Microsurgery on Extremities,Shanghai Jiaotong University Affiliated Sixth People’s Hospital,Shanghai 200233,China [3]Shanghai Center for Systems Biomedicine,Key Laboratory of Systems Biomedicine(Ministry of Education),Shanghai Jiao Tong University,800 Dongchuan Road,Shanghai 200240,China [4]Department of Orthopaedic Surgery,Shanghai Jiao Tong University Affiliated Sixth People’s Hospital,Shanghai 200233,China

出　　处：《Acta Biochimica et Biophysica Sinica》2024年第8期1145-1155,共11页生物化学与生物物理学报（英文版）

基　　金：supported by the grant from the Funding of Shanghai Sixth People Hospital(No.ynms202202).

摘　　要：Glycosylation,a crucial posttranslational modification,plays a significant role in numerous physiological and pathological processes.Lectin microarrays,which leverage the high specificity of lectins for sugar binding,are ideally suited for profiling the glycan spectra of diverse and complex biological samples.In this review,we explore the evolution of lectin detection technologies,as well as the applications and challenges of lectin microarrays in analyzing the glycome profiles of various clinical samples,including serum,saliva,tissues,sperm,and urine.This review not only emphasizes significant advancements in the high-throughput analysis of polysaccharides but also provides insight into the potential of lectin microarrays for diagnosing and managing diseases such as tumors,autoimmune diseases,and chronic inflammation.We aim to provide a clear,concise,and comprehensive overview of the use of lectin microarrays in clinical settings,thereby assisting researchers in conducting clinical studies in glycobiology.

关 键 词：lectin microarray clinical sample GLYCOMICS GLYCANS biomarkers 

分 类 号：Q53[生物学—生物化学]