GLYCANS

作品数：27被引量：24H指数：3
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相关领域：医药卫生生物学更多>>
相关作者：程昉更多>>
相关机构：北京大学大连理工大学大连医科大学美国加州大学更多>>
相关期刊：《International Journal of Ophthalmology(English edition)》《Chemical Research in Chinese Universities》《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》《Molecular Plant》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金高等学校学科创新引智计划更多>>
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Deciphering disease through glycan codes:leveraging lectin microarrays for clinical insights被引量：1
《Acta Biochimica et Biophysica Sinica》2024年第8期1145-1155,共11页Hangzhou Yang Zihan Lin Bo Wu Jun Xu Sheng-Ce Tao Shumin Zhou 
supported by the grant from the Funding of Shanghai Sixth People Hospital(No.ynms202202).
Glycosylation,a crucial posttranslational modification,plays a significant role in numerous physiological and pathological processes.Lectin microarrays,which leverage the high specificity of lectins for sugar binding,...
关键词：lectin microarray clinical sample GLYCOMICS GLYCANS biomarkers 
Sialyltransferase ST3GAL6 silencing reduces α2,3-sialylated glycans to regulate autophagy by decreasing HSPB8-BAG3 in the brain with hepatic encephalopathy
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2024年第6期485-498,共14页Xiaocheng LI Yaqing XIAO Pengfei LI Yayun ZHU Yonghong GUO Huijie BIAN Zheng LI 
supported by the National Natural Science Foundation of China(No.82370592);the Discipline Construction Project of the Health System in Pudong New Area(No.PWZbr2022-15);the Pudong New Area Special Fund for Livelihood Research Project of Science and Technology Development Fund(No.PKJ2021-Y12),China.
End-stage liver diseases,such as cirrhosis and liver cancer caused by hepatitis B,are often combined with hepatic encephalopathy(HE);ammonia poisoning is posited as one of its main pathogenesis mechanisms.Ammonia is c...
关键词：Hepatic encephalopathy HYPERAMMONEMIA AUTOPHAGY ST3β-galactosideα2 3-sialyltransferase 6(ST3GAL6) Heat shock proteinβ8(HSPB8) 
Plant cell wall-mediated disease resistance:Current understanding and future perspectives被引量：1
《Molecular Plant》2024年第5期699-724,共26页Antonio Molina Lucıa Jorda Miguel Angel Torres Marina Martın-Dacal Diego Jose Berlanga Patricia Fernandez-Calvo Elena Gomez-Rubio Sonsoles Martın-Santamarıa 
supported by grant PID2021-126006OB-I00 to A.M.and L.J.;grant PID20220-113588RB-I00 to S.M.-S;funded by MCIN/AEI/10.13039/501100011033;by ERDF A way of making Europe.D.J.B.;supported by PRE2019-091276 and P.F.-C.by postdoctoral fellowships financially supported by the Severo Ochoa Program for Centres of Excellence in R&D(grants SEV-2016-0672 and CEX2020-000999-S);funded by MCIN/AEI/10.13039/501100011033.M.M.-D.was recipient of PhD fellow(PRE2019-08812);funded by MCIN/AEI/10.13039/501100011033.E.G.-R;was supported by Autonomous Region of Madrid fellowship(S2017/BMD-3673);the European Commission-Next Generation EU(Regulation EU2020/2094)through CSIC’s Global Health Platform PTI Salud Global.
Beyond their function as structural barriers,plant cell walls are essential elements for the adaptation of plants to environmental conditions.Cell walls are dynamic structures whose composition and integrity can be al...
关键词：Arabidopsis thaliana cell wall damage-associated molecular patterns DAMPS disease resistance GLYCANS OLIGOSACCHARIDES pattern-triggered immunity PTl pattern recognition receptor PRRs 
Engagement of sialylated glycans with Siglec receptors on suppressive myeloid cells inhibits anticancer immunity via CCL2
《Cellular & Molecular Immunology》2024年第5期495-509,共15页Ronja Wieboldt Michael Sandholzer Emanuele Carlini Chia-wei Lin Anastasiya Börsch Andreas Zingg Didier Lardinois Petra Herzig Leyla Don Alfred Zippelius Heinz Läubli Natalia Rodrigues Mantuano 
supported by funding from the Swiss National Science Foundation(SNSF Grant No.310030-215237/1);the Schoenmakers-Müller Foundation,a research grant from Ono Pharmaceuticals,and the Cancer League of Basel(KlbB).Open access funding provided by University of Basel.
The overexpression of sialic acids on glycans,called hypersialylation,is a common alteration found in cancer cells.Sialylated glycans can enhance immune evasion by interacting with sialic acid-binding immunoglobulin-l...
关键词：sialoglycans Sialic acid-binding immunoglobulin-like lectin tumor microenvironment myeloid derived suppressor cells 
Advances in probing single biomolecules: From DNA bases to glycans
《Interdisciplinary Materials》2023年第4期511-528,共18页Baofei Hou Teng Zhang Huixia Yang Xu Han Liwei Liu Linfei Li Cesare Grazioli Xu Wu Nan Jiang Yeliang Wang 
support of the Beijing Natural Science Foundation(Nos.Z190006 and 4192054);National Key Research and Development Program of China(Nos.2019YFA0308000,2020YFA0308800,and 2021YFA1400100);National Natural Science Foundation of China(Nos.92163206,61971035,61725107,and 62271048);the Strategic Priority Research Program of Chinese Academy of Sciences(No.XDB30000000).
Imaging biomolecules in real space is crucial for gaining a comprehensive understanding of the properties and functions of biological systems at the most fundamental level.Among the various imaging techniques availabl...
关键词：atomic-scale probing biomolecules scanning probe microscopy structure VISUALIZATION 
Immune regulatory networks coordinated by glycans and glycan-binding proteins in autoimmunity and infection被引量：2
《Cellular & Molecular Immunology》2023年第10期1101-1113,共13页SaloméS.Pinho Inês Alves Joana Gaifem Gabriel A.Rabinovich 
supported by grants from SSP:co-funded by the European Union(ERC,GlycanSwitch,101071386).Views and opinions expressed are however those of the author(s)only and do not necessarily reflect those of the European Union or the European Research Council Executive Agency.Neither the European Union nor the granting authority can be held responsible for them.The work was also co-funded by EU GlycanTrigger-grant Agreement No:101093997.Views and opinions expressed are however those of the author(s)only and do not necessarily reflect those of the European Union or European Health and Digital Executive Agency.Neither the European Union nor the granting authority can be held responsible for them.SSP also acknowledges funding by“2022 LRA Lupus Innovation Award”and by“European Crohn’s and Colitis Organisation(ECCO)Pioneer Award 2021”.SSP also acknowledges the US Department of Defense,US Army Medical Research Acquisition Activity,FY18 Peer Reviewed Medical Research Program Investigator-Initiated Research Award(award number W81XWH1920053)as well as grant funded by the Portuguese Foundation for Science and Technology–FCT(EXPL/MED-ONC/0496/2021).IA acknowledges FCT for funding(2022.00337.CEECIND).JG acknowledges funding from ESCMID(ESCMID Research Grant 2022),ECCO(ECCO Grant 2023)and FCT(2020.00088.CEECIND).G.A.R acknowledges grants from the Argentinean Agency for Promotion of Science,Technology and Innovation(PICT 2017-0494,PICT-FBB 620 and PICT 2020-01552).The authors are also thankful for generous support from Sales(Argentina),Bunge&Born(Argentina),Baron(Argentina),Williams(Argentina)and Richard Lounsbery(USA)Foundations,as well as donations from Ferioli-Ostry and Caraballo families to GAR.
The immune system is coordinated by an intricate network of stimulatory and inhibitory circuits that regulate host responses against endogenous and exogenous insults.Disruption of these safeguard and homeostatic mecha...
关键词：Immune response Inflammation INFECTION GLYCANS GLYCOSYLATION Glycan-binding proteins 
Mannosylated glycans impair normal T-cell development by reprogramming commitment and repertoire diversity
《Cellular & Molecular Immunology》2023年第8期955-968,共14页Manuel M.Vicente Inês Alves Ângela Fernandes Ana M.Dias Beatriz Santos-Pereira Elena Pérez-Anton Sofia Santos Tao Yang Alexandra Correia Anja Münster-Kühnel Afonso R.M.Almeida Sarina Ravens Gabriel A.Rabinovich Manuel Vilanova Ana E.Sousa SaloméS.Pinho 
Funded by the“2022 Lupus Research Alliance(LRA)Lupus Innovation Award”.Institutional funding from the Portuguese Foundation for Science and Technology(FCT):projects NORTE-01-0145-FEDER-000029,POCI-01/0145-FEDER-016601,POCI-01-0145-FEDER-028772,and PTDC/MEC-REU/28772/2017(SSP);This study was co-funded by the European Union(ERC Synergy,GlycanSwitch,101071386);Views and opinions expressed are,however,those of the author(s)only and do not necessarily reflect those of the European Union or the European Research Council Executive Agency.The study was also co-funded by the European Union,GlycanTrigger project,Grant Agreement No:101093997;Views and opinions expressed are,however,those of the author(s)only and do not necessarily reflect those of the European Union or European Health and Digital Executive Agency.Neither the European Union nor the granting authority can be held responsible for them.A grant was received from the Portuguese group of study in autoimmune diseases(NEDAI)to SSP.MMV(PD/BD/135452/2017,COVID/BD/152488/2022)received funding from the FCT.
T-cell development ensures the formation of diverse repertoires of T-cell receptors(TCRs)that recognize a variety of antigens.Glycosylation is a major posttranslational modification present in virtually all cells,incl...
关键词：N-glycosylation T-cell development THYMOCYTES GLYCOCALYX Inflammation 
人类蛋白质N-糖基化的十二年全基因组关联研究
《Engineering》2023年第7期17-31,I0001,I0002,共17页Anna Timoshchuk Sodbo Sharapov Yurii S.Aulchenko 
an output of a research project implemented as part of the Research Program at the Moscow State University (MSU) Institute for Artificial Intelligence.
Most human-secreted and membrane-bound proteins have covalently attached oligosaccharide chains or glycans.Glycosylation influences the physical and chemical properties of proteins,as well as their biological function...
关键词：GLYCOME GLYCANS N-GLYCOSYLATION Genomics Genetics GWAS 
High Mannose-Specific Aptamers for Broad-Spectrum Virus Inhibition and Cancer Targeting
《CCS Chemistry》2023年第2期497-509,共13页Wei Li Shuxin Xu Ying Li Jingran Chen Yanyan Ma Zhen Liu 
supported by the National Key Research and Development Program of China(grant no.2018YFC0910301)from the Ministry of Science and Technology of China,the Key Grant(grant no.21834003)from the National Natural Science Foundation of China,and the Excellent Research Program of Nanjing University(grant no.ZYJH004)to Z.L.
High mannose oligosaccharides are characteristic and essential for immune evasion of many viruses and cancer cells.They are potential targets for viral inhibition and cancer diagnosis/therapy.Particularly,high mannose...
关键词：APTAMER high mannose glycans VIRUS cancer molecular recognition 
The team of Prof. Xinshan Ye has made a major breakthrough in the field of automated multiplicative synthesis of complex glycans
《Journal of Chinese Pharmaceutical Sciences》2022年第10期800-802,共3页无 
2022年9月29日,北京大学药学院天然药物及仿生药物国家重点实验室叶新山研究团队在《自然-合成》(NatureSynthesis)上在线发表了题为《自动液相乘法合成复杂聚糖到1080糖》(Automated solution-phase multiplicative synthesis of compl...
关键词：糖类化合物 自动合成 synthesis 
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