GLYCOMICS

作品数：13被引量：13H指数：2
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Deciphering disease through glycan codes:leveraging lectin microarrays for clinical insights被引量：1
《Acta Biochimica et Biophysica Sinica》2024年第8期1145-1155,共11页Hangzhou Yang Zihan Lin Bo Wu Jun Xu Sheng-Ce Tao Shumin Zhou 
supported by the grant from the Funding of Shanghai Sixth People Hospital(No.ynms202202).
Glycosylation,a crucial posttranslational modification,plays a significant role in numerous physiological and pathological processes.Lectin microarrays,which leverage the high specificity of lectins for sugar binding,...
关键词：lectin microarray clinical sample GLYCOMICS GLYCANS biomarkers 
Recent advances in N-glycan biomarker discovery among human diseases被引量：1
《Acta Biochimica et Biophysica Sinica》2024年第8期1156-1171,共16页Yi Wang Yuanyuan Liu Si Liu Liming Cheng Xin Liu 
supported by the grants from the National Key Research and Development Program of China(No.2022YFC3400800);the National Natural Science Foundation of China(No.82272418).
N-glycans play important roles in a variety of biological processes.In recent years,analytical technologies with high resolution and sensitivity have advanced exponentially,enabling analysts to investigate N-glycomic ...
关键词：N-GLYCAN GLYCOMICS BIOMARKER DIAGNOSIS PROGNOSIS 
N-glycan biosignatures as a potential diagnostic biomarker for earlystage pancreatic cancer
《World Journal of Gastrointestinal Oncology》2024年第3期659-669,共11页Yan-Rong Wen Xia-Wen Lin Yu-Wen Zhou Lei Xu Jun-Li Zhang Cui-Ying Chen Jian He 
fundings for Clinical Trials from the Affiliated Drum Tower Hospital,Medical School of Nanjing University,No.2021-LCYJ-MS-11.
BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)has a poor prognosis,with a 5-year survival rate of less than 10%,owing to its late-stage diagnosis.Early detection of pancreatic cancer(PC)can significantly increase s...
关键词：GLYCOMICS N-GLYCANS Biomarkers Pancreatic cancer Predictive modeling 
Cloning,Expressing and Characterizing a Novel Cold-Adapted Laminarinase from Marine Bacterium Wenyingzhuangia aestuarii OF219
《Journal of Ocean University of China》2023年第4期1034-1040,共7页LI Jiajing XUE Changhu CHANG Yaoguang SHEN Jingjing ZHANG Yuying 
supported by the National Key R&D Program of China(No.2018YFC0311203);the Fundamental Research Funds for the Central Universities(No.201941005).
Laminarinases reveal potential application in the field of food and biotechnology.In this research,a novel GH16 family laminarinase,designated as Lam16A_Wa,was cloned from the genome of marine bacterium Wenyingzhuangi...
关键词：laminarinase LAMINARIN GLYCOMICS GH16 family 
结直肠癌、基质和正常结肠黏膜显微解剖区域N-糖组的显著多样性
《Engineering》2023年第7期32-43,I0002,共13页Di Wang Katarina Madunic Tao Zhang Guinevere S.M.Lageveen-Kammeijer Manfred Wuhrer 
supported by the China Scholarship Council.
Aberrant glycosylation is considered to be a hallmark of colorectal cancer(CRC),as demonstrated by various studies.While the N-glycosylation of cell lines and serum has been widely examined,the analysis of cancer-asso...
关键词：Colorectal cancer Tumor Porous graphitized carbon liquid chromatography mass spectrometry N-glycomics Antibody response 
Protein O-GlcNAcylation in cardiovascular diseases被引量：2
《Acta Pharmacologica Sinica》2023年第1期8-18,共11页Hui-fang Wang Yi-xuan Wang Yu-ping Zhou Yun-peng Wei Yi Yan Ze-jian Zhang Zhi-cheng Jing 
We thank Professor Ji-wang Chen(from Cardiovascular Research Center,University of Illinois at Chicago)for carefully proofreading this manuscript.This work was supported by the CAMS Innovation Fund for Medical Sciences(No.2021-I2M-1-018),and Ningxia Hui Autonomous Region Key Research and Development Project(No.2019BFG02027).
O-GlcNAcylation is a post-translational modification of protein in response to genetic variations or environmental factors,which is controlled by two highly conserved enzymes,i.e.O-GlcNAc transferase(OGT)and protein O...
关键词：O-GLCNACYLATION GLYCOMICS GLYCOSYLATION cardiovascular disease 
Updated clinical and glycomic features of mannosyl-oligosaccharide glucosidase deficiency:Two case reports被引量：2
《World Journal of Clinical Cases》2022年第21期7397-7408,共12页Kuerbanjiang Abuduxikuer Lei Wang Lin Zou Cui-Yan Cao Long Yu Hong-Mei Guo Xin-Miao Liang Jian-She Wang Li Chen 
Supported by National Science and Technology Major Project,No.2014ZX09101046-004(to Chen L);National Natural Science Foundation of China,Nos.81873543 and 81570468(to Wang JS).
BACKGROUND Mannosyl-oligosaccharide glucosidase(MOGS)deficiency is an extremely rare type of congenital disorder of glycosylation(CDG),with only 12 reported cases.Its clinical,genetic,and glycomic features are still e...
关键词：Mannosyl-oligosaccharide glucosidase MOGS-CDG Congenital disorder of glycosylation type IIb Mannosyl-oligosaccharide glucosidase gene Glycomics of IgG1 Case report 
Single-cell omics analyses with single molecular detection:challenges and perspectives被引量：4
《The Journal of Biomedical Research》2021年第4期264-276,共13页Gradimir Misevic 
The ultimate goal of single-cell analyses is to obtain the biomolecular content for each cell in unicellular and multicellular organisms at different points of their life cycle under variable environmental conditions....
关键词：single-cell analyses single molecular detection ome transcriptomics proteomics GLYCOMICS LIPIDOMICS metabolomics 
N-glycans released from glycoproteins using a commercial kit and comprehensively analyzed with a hypothetical database
《Journal of Pharmaceutical Analysis》2017年第2期87-94,共8页Xue Sun Lei Tao Lin Yi Yilan Ouyang Naiyu Xu Duxin Li Robert J.Linhardt Zhenqing Zhang 
the National Natural Science Foundation of China (81473179 and 81673388);Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD, YX13200111);the funding for Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-PsychoDiseases (BM2013003)
The glycosylation of proteins is responsible for their structural and functional roles in many cellular activities.This work describes a strategy that combines an efficient release, labeling and liquid chromatography...
关键词：N-glycan Hypothetical database Glycoproteins Gastric carcinoma cells Glycomics 
Advancements in mass spectrometry-based glycoproteomics and glycomics被引量：4
《National Science Review》2016年第3期345-364,共20页Haojie Lu Ying Zhang Pengyuan Yang 
partial financial support from the National Basic Research Program of China(2013CB911201,2013CB910502,2011CB910600,2014CBA020-00);the National Natural Science Foundation of China(31570825,21227805);National High-tech R&D Program of China(2012AA020203)
Protein N-glycosylation plays a crucial role in a considerable number of important biological processes.Research studies on glycoproteomes and glycomes have already characterized many glycoproteins and glycans associa...
关键词：MASS SPECTROMETRY GLYCOPROTEOMICS GLYCOMICS 
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