Protein O-GlcNAcylation in cardiovascular diseases  

作　　者：Hui-fang Wang Yi-xuan Wang Yu-ping Zhou Yun-peng Wei Yi Yan Ze-jian Zhang Zhi-cheng Jing 

机构地区：[1]Department of Medical Laboratory,Weifang Medical University,Weifang,261053,China [2]Department of Cardiology,State Key Laboratory of Complex Severe and Rare Diseases,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,100730,China [3]Institute for Cardiovascular Prevention(IPEK),Ludwig-Maximilians-University Munich,Munich,Germany [4]DZHK(German Centre for Cardiovascular Research),Partner Site Munich Heart Alliance,Munich,Germany [5]Medical Research Center,State Key Laboratory of Complex Severe and Rare Diseases,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,100730,China

出　　处：《Acta Pharmacologica Sinica》2023年第1期8-18,共11页中国药理学报（英文版）

基　　金：We thank Professor Ji-wang Chen(from Cardiovascular Research Center,University of Illinois at Chicago)for carefully proofreading this manuscript.This work was supported by the CAMS Innovation Fund for Medical Sciences(No.2021-I2M-1-018),and Ningxia Hui Autonomous Region Key Research and Development Project(No.2019BFG02027).

摘　　要：O-GlcNAcylation is a post-translational modification of protein in response to genetic variations or environmental factors,which is controlled by two highly conserved enzymes,i.e.O-GlcNAc transferase(OGT)and protein O-GlcNAcase(OGA).Protein O-GlcNAcylation mainly occurs in the cytoplasm,nucleus,and mitochondrion,and it is ubiquitously implicated in the development of cardiovascular disease(CVD).Alterations of O-GlcNAcylation could cause massive metabolic imbalance and affect cardiovascular function,but the role of O-GlcNAcylation in CVD remains controversial.That is,acutely increased O-GlcNAcylation is an adaptive heart response,which temporarily protects cardiac function.While it is harmful to cardiomyocytes if O-GlcNAcylation levels remain high in chronic conditions or in the long run.The underlying mechanisms include regulation of transcription,energy metabolism,and other signal transduction reactions induced by O-GlcNAcylation.In this review,we will focus on the interactions between protein O-GlcNAcylation and CVD,and discuss the potential molecular mechanisms that may be able to pave a new avenue for the treatment of cardiovascular events.

关 键 词：O-GLCNACYLATION GLYCOMICS GLYCOSYLATION cardiovascular disease 

分 类 号：R54[医药卫生—心血管疾病]