云南高校图书馆联盟文献共享服务平台- N-GLYCAN

N-GLYCAN: 作品数：22被引量：38H指数：3; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：刘欣刘笔锋孙桂芹李天胜陈力更多>>; 相关机构：浙江大学华中科技大学沃特世科技(上海)有限公司复旦大学更多>>; 相关期刊：《Science China Chemistry》《World Journal of Gastroenterology》《Advances in Biological Chemistry》《微生物与感染》更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划宁波市自然科学基金国家科技重大专项更多>>

Integration of resol/block-copolymer carbonization and machine learning:A convenient approach for precise monitoring of glycan-associated disorders: 《Chinese Chemical Letters》2024年第12期482-486,共5页Yiwen Lin Yijie Chen Chunhui Deng Nianrong Sun; supported by National Key R&D Program of China(No.2018YFA0507501);the National Natural Science Foundation of China(Nos.22074019,21425518,22004017);Shanghai Sailing Program(No.20YF1405300)。; Ensuring the timely and precise monitoring of severe liver diseases is crucial for guiding effective therapies and significantly extending overall quality of life.However,this remains a worldwide challenge,given the h...; 关键词：N-GLYCAN Mesoporous carbon MALDI-TOF MS Machine learning model Liver disease

Diagnostic value of exosomal N-glycan profiles for microvascular invasion in hepatocellular carcinoma: 《iLABMED》2024年第4期238-247,共10页Huijuan Feng Junping Ke Liping Zheng Chenjun Huang Lijuan Liu; Fuzhou“14th Five-Year”Clinical Key Specialty,Grant/Award Number:20220203;Natural Science Foundation of Fujian Province,Grant/Award Number:2020J011169。; Background:Microvascular invasion(MVI)was a critical high-risk factor for postoperative recurrence and adverse prognosis in patients with hepatocellular carcinoma(HCC),and there were no reliable non-invasive pre-opera...; 关键词：EXOSOME hepatocellular carcinoma microvascular invasion N-glycan profile

Targeted protein editing technique in living mammalian cells by peptide-fused PNGase: 《hLife》2024年第11期576-591,共16页Min Wu Guijie Bai Ziyi Zhang Haixia Xiao Wenliang Sun Chaoguang Tian; supported by funding from the Key Project of the Ministry of Science and Technology of China(2018YFA0900500).; Various precise gene editing techniques at the DNA/RNA level,driven by clustered regularly interspaced short palindrome repeats(CRISPR)/CRISPR-associated protein 9(Cas9)technology,have gained significant prominence.Ye...; 关键词：N-glycosylated proteins peptide:N-glycanase(PNGase) protein-targeting peptides DEGLYCOSYLATION protein sequence editing protein degradation

Recent advances in N-glycan biomarker discovery among human diseases被引量：1: 《Acta Biochimica et Biophysica Sinica》2024年第8期1156-1171,共16页Yi Wang Yuanyuan Liu Si Liu Liming Cheng Xin Liu; supported by the grants from the National Key Research and Development Program of China(No.2022YFC3400800);the National Natural Science Foundation of China(No.82272418).; N-glycans play important roles in a variety of biological processes.In recent years,analytical technologies with high resolution and sensitivity have advanced exponentially,enabling analysts to investigate N-glycomic ...; 关键词：N-GLYCAN GLYCOMICS BIOMARKER DIAGNOSIS PROGNOSIS

N-glycan biosignatures as a potential diagnostic biomarker for earlystage pancreatic cancer: 《World Journal of Gastrointestinal Oncology》2024年第3期659-669,共11页Yan-Rong Wen Xia-Wen Lin Yu-Wen Zhou Lei Xu Jun-Li Zhang Cui-Ying Chen Jian He; fundings for Clinical Trials from the Affiliated Drum Tower Hospital,Medical School of Nanjing University,No.2021-LCYJ-MS-11.; BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)has a poor prognosis,with a 5-year survival rate of less than 10%,owing to its late-stage diagnosis.Early detection of pancreatic cancer(PC)can significantly increase s...; 关键词：GLYCOMICS N-GLYCANS Biomarkers Pancreatic cancer Predictive modeling

Exploiting Complex-Type N-Glycan to Improve the in Vivo Stability of Bioactive Peptides被引量：1: 《CCS Chemistry》2023年第7期1623-1634,共12页Qijia Wei Jun Zhang Yuankun Dao Mengliang Ye Dangliang Liu Weidong Dong Ning Yuan Hongxing Li Chunli Song Mo Li Xiaomeng Shi Suwei Dong; This research was made possible as a result of a generous grant from the Beijing National Science Foundation(grant no.JQ18024);the National Key R&D Program of China(grant no.2018YFA0507602);the National Natural Science Foundation of China(grant nos.91953111 and 91853113).; Peptides can be potentmolecules with high efficacy and selectivity in the development of biotherapeutics.However,the poor pharmacokinetic properties of peptides pose major challenges for their broader medicinal applic...; 关键词：therapeutic peptides STABILITY Nglycosylation solid-phase peptide synthesis chemoenzymatic approach hydrogen-deuterium exchange mass spectrometry

血清N-聚糖生物标志物诊断ALT水平正常慢性乙型肝炎患者显著肝纤维化和肝硬化的临床意义被引量：1: 《Engineering》2023年第7期151-158,I0006,共9页王林刘艺琪顾启馨张驰徐蕾王蕾陈翠英刘学恩赵鸿庄辉; supported by the Major Science and Technology Special Project of China Thirteenth Five-year Plan(2018ZX10732401-003-015);the National Science and Technology Major Project(2013ZX10002005 and 2017ZX10203202)。; 本研究目的是探讨血清N-聚糖模型在285例丙氨酸转移酶(alanine aminotransferase,ALT)水平正常(<40 U·L^(-1))的慢性乙型肝炎(慢性乙肝)患者中诊断显著肝纤维化和肝硬化的临床意义。入组患者均进行肝组织活检,并使用Ishak评分系统评估...; 关键词：Liver fibrosis Chronic hepatitis B Serum N-glycan N-glycan model Alanine aminotransferase(ALT)level

An innovative method used for the identification of N-glycans on soybean allergenβ-conglycinins被引量：1: 《Food Science and Human Wellness》2023年第3期842-850,共9页Cheng Li Yang Tian Jianli Han Yu Lu Meiyi Zou Yue Jia Chengjian Wang Linjuan Huang Zhongfu Wang; funded by National Natural Science Foundation of China(31870798,31972024);Shaanxi Province Innovation Capability Support Plan-Science and Technology Innovation Team(2020TD-044);Key Laboratory of Glycobiology and Glycoengineering of Xi’an(2019219514SYS010CG032);Natural Science Project of Shaanxi Provincial Department of Education(21JK0929);Science and Technology Resources Sharing Platform Project of Science and Technology Department in Shaanxi Province(2022PT-46)。; β-Conglycinin is one of the major allergens existed in soybean.N-Glycans attached to theβ-conglycinin influenced the immunoreactivity and antigen presenting efficiency ofβ-conglycinin.In this study,we described a n...; 关键词：Soybean allergenβ-conglycinin GLYCOPEPTIDE Mass spectrometry N-GLYCAN Glycosylation site

Fragmentation stability and retention time-shift obtained by LC-MS/MS to distinguish sialylated N-glycan linkage isomers in therapeutic glycoproteins: 《Journal of Pharmaceutical Analysis》2023年第3期305-314,共10页Chi Soo Park Minju Kang Ahyeon Kim Chulmin Moon Mirae Kim Jieun Kim Subin Yang Leeseul Jang Ji Yeon Jang Ha Hyung Kim; supported by the Basic Science Research Program through the National Research Foundation of Korea(NRF)and funded by the Ministry of Education,Korea(Grant No.:2021R1A6A1A03044296);This study was supported by the Chung-Ang University Graduate Research Scholarship in 2022.; Sialylated N-glycan isomers withα2-3 orα2-6 linkage(s)have distinctive roles in glycoproteins,but are difficult to distinguish.Wild-type(WT)and glycoengineered(mutant)therapeutic glycoproteins,cytotoxic T lymphocyte...; 关键词：Therapeutic glycoprotein SIALYLATION Linkage isomer LC-MS/MS

Application of StrucGP in medical immunology:site-specific N-glycoproteomic analysis of macrophages: 《Frontiers of Medicine》2023年第2期304-316,共13页Pengfei Li Zexuan Chen Shanshan You Yintai Xu Zhifang Hao Didi Liu Jiechen Shen Bojing Zhu Wei Dan Shisheng Sun; supported by the National Key Research and Development Program of China(No.2019YFA0905200);the National Natural Science Foundation of China(Nos.91853123,81773180,and 21705127).; The structure of N-glycans on specific proteins can regulate innate and adaptive immunity via sensing environmental signals.Meanwhile,the structural diversity of N-glycans poses analytical challenges that limit the ex...; 关键词：macrophage GLYCOPROTEOME GLYCOPEPTIDES N-glycan structures PD-L1

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