Glycosylation in the tumor immune response:the bitter side of sweetness  

作　　者：Yuting Cao Wen Yi Qiang Zhu 

机构地区：[1]Department of Biochemistry,College of Life Sciences,Zhejiang University,Hangzhou 310058,China

出　　处：《Acta Biochimica et Biophysica Sinica》2024年第8期1184-1198,共15页生物化学与生物物理学报（英文版）

基　　金：supported by the grants from the National Natural Science Foundation of China(Nos.92353303 to W.Y.,and 32201045 to Q.Z).

摘　　要：Glycosylation is the most structurally diverse form of post-translational modification(PTM)of proteins that affects a myriad of cellular processes.As a pivotal regulator of protein homeostasis,glycosylation notably impacts the function of proteins,spanning from protein localization and stability to protein-protein interactions.Aberrant glycosylation is a hallmark of cancer,and extensive studies have revealed the multifaceted roles of glycosylation in tumor growth,migration,invasion and immune escape Over the past decade,glycosylation has emerged as an immune regulator in the tumor microenvironment(TME).Here,we summarize the intricate interplay between glycosylation and the immune system documented in recent literature,which orchestrates the regulation of the tumor immune response through endogenous lectins,immune checkpoints and the extracellular matrix(ECM)in the TME.In addition,we discuss the latest progress in glycan-based cancer immunotherapy.This review provides a basic understanding of glycosylation in the tumor immune response and a theoretical framework for tumor immunotherapy.

关 键 词：GLYCOSYLATION immune response endogenous lectins immune checkpoint extracellular matrix immunotherapy 

分 类 号：R730.51[医药卫生—肿瘤]