Which characteristics are associated with changes in medication status for lower urinary tract symptoms among patients with prostate cancer receiving external beam radiotherapy?  

作　　者：Yuki Kyoda Kohei Hashimoto Atsushi Takahashi TakeshiMaehana Kimihito Tachikawa Takashi Muranaka Shuichi Kato Tomoyo Kurisug Fumimasa Fukuta Takahiro Kirisawa Manabu Okada Ko Kobayashi Toshiaki Tanaka Shiro Hinotsu Naoya Masumoria 

机构地区：[1]Department of Urology,SapporoMedical University School of Medicine,Sapporo,Japan [2]Department of Urology,Hakodate Goryoukaku Hospital,Hakodate,Japan [3]Department of Urology,Muroran City General Hospital,Muroran,Japan [4]Department of Urology,NTT-East Sapporo Hospital,Sapporo,Japan [5]Department of Urology,Sunagawa City Medical Center,Sunagawa,Japan [6]Department of Urology,Oji General Hospital,Tomakomai,Japan [7]Department of Urology,Steel Memorial Muroran Hospital,Muroran,Japan [8]Department of Urology,Obihiro Kyokai Hospital,Obihiro,Japan [9]Department of Medical Statistics,Sapporo Medical University School of Medicine,Sapporo,Japan

出　　处：《Current Urology》2024年第2期122-127,共6页当代泌尿学（英文）

摘　　要：Background:We clarified the predictive factors for changes in the status ofmedications for lower urinary tract symptoms(LUTS)2 years after local radiotherapy for nonmetastatic prostate cancer.Materials and methods:We retrospectively included patients who underwent local external radiotherapy for nonmetastatic prostate cancer in 8 institutions between April 2001 and March 2016.Patients were divided into themedication and no-medication group based on the use of drugs for LUTS before radiotherapy.We defined improvement of LUTS as when the patient did not require medication for LUTS at 24 months after radiotherapy in the medication group and as deterioration whenmedication was required in the no-medication group.Logistic regression analysis was used to evaluate predictive factors for changes in medication status.Results:Altogether,505 patients were divided into a no-medication group(n=352)and a medication group(n=153).The number of patients with deterioration and improvement in LUTS was 49(14%)and 36(23%),respectively.In the multivariate analysis,the predictive variables for deterioration were the International Prostate SymptomScore(≥8;odds ratio[OR],2.21;p=0.014)and the biopsy Gleason score(≤3+4=7;OR,2.430;p=0.008)in the no-medication group,whereas those for improvement were age(<75 years old;OR,5.81;p=0.002),the quality of life score(<3;OR,3.15;p=0.028),and a positive biopsy core rate(≥50%;OR,2.530;p=0.027)in the medication group.Conclusions:These predictive factors for changes in the status ofmedications for LUTS at 2 years after external radiotherapymay help determine the definitive therapy for nonmetastatic prostate cancer.

关 键 词：Prostate cancer RADIOTHERAPY Lower urinary tract symptoms MEDICATIONS 

分 类 号：R737.25[医药卫生—肿瘤]