Epigenetics and environmental health  

作　　者：Min Zhang Ting Hu Tianyu Ma Wei Huang Yan Wang 

机构地区：[1]Key Laboratory of Cancer and Microbiome,State Key Laboratory of Molecular Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,100021,China [2]Beijing Key Laboratory of Cancer Invasion and Metastasis Research,Department of Biochemistry and Molecular Biology,School of Basic Medical Sciences,Capital Medical University,Beijing,100069,China

出　　处：《Frontiers of Medicine》2024年第4期571-596,共26页医学前沿（英文版）

基　　金：supported by grants from National Natural Science Foundation of China(Nos.41931291,42125707,82273403);Major State Basic Research Development Program of China(No.2022YFA1103402);Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(Nos.2019PT310027 and 2021-RC310-006);Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(No.2021-I2M-1-018).

摘　　要：Epigenetic modifications including DNA methylation,histone modifications,chromatin remodeling,and RNA modifications complicate gene regulation and heredity and profoundly impact various physiological and pathological processes.In recent years,accumulating evidence indicates that epigenetics is vulnerable to environmental changes and regulates the growth,development,and diseases of individuals by affecting chromatin activity and regulating gene expression.Environmental exposure or induced epigenetic changes can regulate the state of development and lead to developmental disorders,aging,cardiovascular disease,Alzheimer's disease,cancers,and so on.However,epigenetic modifications are reversible.The use of specific epigenetic inhibitors targeting epigenetic changes in response to environmental exposure is useful in disease therapy.Here,we provide an overview of the role of epigenetics in various diseases.Furthermore,we summarize the mechanism of epigenetic alterations induced by different environmental exposures,the influence of different environmental exposures,and the crosstalk between environmental variation epigenetics,and genes that are implicated in the body's health.However,the interaction of multiple factors and epigenetics in regulating the initiation and progression of various diseases complicates clinical treatments.We discuss some commonly used epigenetic drugs targeting epigenetic modifications and methods to prevent or relieve various diseases regulated by environmental exposure and epigenetics through diet.

关 键 词：EPIGENETICS environmental exposure HEALTH prevention and therapy 

分 类 号：R394[医药卫生—医学遗传学]