神经系统遗传疾病脑类器官模型构建的优势与挑战  

Advantages and challenges of brain organoid modeling for genetic diseases of the nervous system

作　　者：黄丝琪 杨影虹 孙筱放[1] 谢英俊[1] Huang Siqi;Yang Yinghong;Sun Xiaofang;Xie Yingjun(Department of Obstetrics and Gynecology,the Third Affiliated Hospital of Guangzhou Medical University,Guangdong Provincial Key Laboratory of Major Obstetric Diseases,Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology,Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine,Guangzhou 510150,China)

机构地区：[1]广州医科大学附属第三医院妇产科实验部科研平台、广东省产科重大疾病重点实验室、广东省妇产疾病临床医学研究中心、粤港澳母胎医学高校联合实验室,广州510150

出　　处：《中华神经科杂志》2024年第9期1030-1036,共7页Chinese Journal of Neurology

基　　金：广东省科学技术厅协同创新与平台环境建设-国际科技合作项目专题(2020A0505100062);广东省自然科学基金(2024A1515012233);广州市科学技术厅市校(院)联合资助项目(2023A03J0386)。

摘　　要：脑类器官是由人类胚胎干细胞或人类诱导多能干细胞产生的自组织3D聚集体,其细胞类型和结构类似于胚胎人脑,是一个研究神经遗传疾病的良好体外模型,已在神经遗传疾病研究中较为广泛应用。文中将探讨脑类器官在神经系统遗传疾病模型构建中的优势与挑战。Brain organoids are self-organized 3D aggregates generated by human embryonic stem cells or human induced pluripotent stem cells.Their cell type and structure are similar to embryonic human brain,which are good in vitro models for the study of neurogenetic diseases and have been widely used in the study of neurogenetic diseases.This paper will discuss the advantages and challenges of brain organoids in the modeling of genetic diseases of the nervous system.

关 键 词：脑类器官 神经遗传疾病 诱导多能干细胞 疾病模型 

分 类 号：R741[医药卫生—神经病学与精神病学]