高脂、高脂高果糖饮食对大鼠高尿酸血症的影响  

Effect of high fat,high fat and high fructose diet on hyperuricemia in rats

作　　者：车荧娟 陈妍[1] 陈婷婷[1] 罗舜菁[1] 刘成梅[1,2] CHE Yingjuan;CHEN Yan;CHEN Tingting;LUO Shunjing;LIU Chengmei(State Key Laboratory of Food Science and Technology,Nanchang University,Nanchang,Jiangxi 330047,China;International Institute of Food Innovation Co.,Ltd.,Nanchang University,Nanchang,Jiangxi 330200,China)

机构地区：[1]南昌大学食品科学与技术国家重点实验室,江西南昌330047 [2]江西南大国创院食品科技有限公司,江西南昌330200

出　　处：《食品与机械》2024年第7期126-131,共6页Food and Machinery

基　　金：江西省“双千计划”科技创新高端人才项目-自然科学类(编号:jxsq2023201042);江西省重点研发计划(编号:20232BBF60023);江西省中央引导地方科技发展资金项目(编号:20221ZDD02001);全国重点实验室项目(编号:20232BCD44005)。

摘　　要：[目的]探究高脂饮食与高脂高果糖饮食对高尿酸血症(HUA)大鼠尿酸水平及肝肾功能的影响。[方法]将24只大鼠随机均分为对照组、模型组、高脂饮食组和高脂高果糖饮食组,除对照组外各组大鼠每天灌胃500 mg/kg氧嗪酸钾和100 mg/kg腺嘌呤,采用相应饲料饲喂;6周后测定尿酸、肌酐等血清生化指标,并对肾脏、肝脏进行病理学检查。[结果]对照组、模型组、高脂饮食组和高脂高果糖饮食组尿酸含量分别为118.10,319.05,325.71,456.10μmol/L。高脂饮食组尿酸、肌酐水平与模型组无显著差异,但肾脏损伤及肝脏脂肪积累更严重。高脂高果糖组尿酸显著高于模型组,且肾脏损伤及肝脏脂肪积累程度比模型组严重。[结论]高脂饮食不会进一步升高HUA大鼠尿酸含量,但会加重已患HUA大鼠的肝肾损伤。高脂高果糖饮食会进一步升高HUA大鼠尿酸含量,且加重肾脏损伤及肝脏脂肪积累程度。高尿酸血症群体应注意控制饮食中脂肪及果糖的摄入。[Objective]This study aimed to investigate the effects of high fat diet and high fat and high fructose diet on uric acid level and liver and kidney function in hyperuricemia(HUA)rats.[Methods]24 rats were randomly divided into control group,model group,high-fat diet group and high-fat and high-fructose diet group.All rats were fed with the corresponding diets,except the control group,500 mg/kg potassium oxazinate and 100 mg/kg adenine per day.After 6 weeks,serum biochemical indexes such as uric acid and creatinine were determined,and pathological examination of kidney and liver was performed.[Results]The uric acid content of control group,model group,high-fat diet group and high-fat high-fructose diet group were 118.10,319.05,325.71,456.10μmol/L,respectively.The levels of uric acid and creatinine in the high-fat diet group were not significantly different from those in the model group,but the kidney injury and liver fat accumulation were more serious.The uric acid in the high-fat and high-fructose group was significantly higher than that in the model group,and the degree of kidney injury and liver fat accumulation was more serious than that in the model group.[Conclusion]High-fat diet cannot further increase the uric acid content of HUA rats,but can aggravate the liver and kidney damage of HUA rats.High-fat and high-fructose diet will further increase the uric acid content of HUA rats,and aggravate kidney injury and liver fat accumulation.Hyperuricemia group should pay attention to control the intake of dietary fat and fructose.

关 键 词：高尿酸血症 腺嘌呤 高脂饮食 高脂高果糖饮食 

分 类 号：R589.7[医药卫生—内分泌]