Coleus forskohlii shows anti-psoriatic activity in imiquimod-induced psoriasis rats  

作　　者：Sagarika Majhi Iti Chauhan Deepak Kumar Md.Niyaz Alam Md.Sarfaraj Hussain Muzaffar Iqbal 

机构地区：[1]Faculty of Pharmacy,I.T.S College of Pharmacy,Muradnagar,Ghaziabad,U.P.India [2]Lord Buddha Koshi Pharmacy College of Pharmacy,Baijanathpur,NH 107,Saharsa(Bihar)852201,India [3]Department of Pharmaceutical Chemistry,College of Pharmacy,King Saud University,P.O.Box 2457,Riyadh 11451,Saudi Arabia

出　　处：《Asian Pacific Journal of Tropical Biomedicine》2024年第9期382-390,I0002-I0007,共15页亚太热带生物医学杂志（英文版）

基　　金：supported by Researchers Supporting Project number(RSPD2024R734);King Saud University,Riyadh,Saudi Arabia.

摘　　要：Objective:To evaluate anti-psoriatic activity of Coleus forskohlii in rats with imiquimod-induced psoriasis.Methods:Imiquimod was used to induce psoriasis in rats.Body weight,skin thickness,erythema,scaling,spleen weight,and histological alternations were measured to assess the effect of Coleus forskohlii.Furthermore,an emulgel formulation containing Coleus forskohlii 10%was prepared and characterized along with its ex vivo permeation studies.Results:The emulgel formulation containing Coleus forskohlii 10%had a pH of 5.40±0.36,with optimum spreadability of(31.67±2.08)g/(cm·s)and viscosity of(15966.67±1274.10)cps,and enhanced both the rate and the extent of drug permeation through psoriatic skin.In an ex vivo study,the quantity of drug permeated(19.18%),deposited(52.38%),and drug remaining in the donor compartments(28.31%)was satisfactory.Coleus forskohlii significantly alleviated imiquimod-induced psoriasis by increasing glutathione and superoxide dismutase activity,decreasing malondialdehyde and nitric oxide levels,and alleviating histological alternations in rat skin.Conclusions:Coleus forskohlii can alleviate imiquimod-induced psoriasis,which may be used as a therapeutic candidate for the treatment of psoriasis.

关 键 词：PSORIASIS Coleus forskohlii Emulgel Ex vivo IMIQUIMOD CARBOPOL 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]