Balloon cells in malformations of corticaldevelopment:friends or foes?  

作　　者：Zili Liu Xuefeng Shen Kaomin Lin Fengpeng Wang Jin Gao Yi Yao Jianyuan Sun 

机构地区：[1]CAS Key Laboratory of Brain Connectome and Manipulation,Shenzhen-Hong Kong Institute of Brain Science,Shenzhen Institute of Advanced Technology(SIAT),Chinese Academy of Sciences,Shenzhen 518055,China [2]The Brain Cognition and Brain Disease Institute,SIAT,CAS,Shenzhen 518055,China [3]Epilepsy Center,Fujian Medical University Affiliated Xiamen Humanity Hospital,Xiamen 361003,China [4]Department of Pathology,Fujian Medical University Affiliated Xiamen Humanity Hospital,Xiamen 361003,China [5]HH-SIAT Joint Center for Epilepsy Research,Fujian Medical University Affiliated Xiamen Humanity Hospital,Xiamen 361003,China

出　　处：《Acta Epileptologica》2024年第2期87-99,共13页癫痫学报（英文）

基　　金：supported by the National Science and Technology Innovation 2030-Major Project of China(2021ZD0202500,to JS);The Joint Funds of the National Natural Science Foundation of China(U20A6005,to JS);National Natural Science Foundation of China(32100765,to ZL);Natural Science Foundation of Guangdong Province(2022A1515010297,to XS);Shenzhen-Hong Kong-Macao Science and Technology Innovation Project(SGDX2020110309280100,to YY);Xiamen Medical health science and technology project(3502Z20194098,to FW).

摘　　要：Balloon cells(BCs)are specific pathological marker of cortical malformations during brain development,often associ-ated with epilepsy and development delay.Although a large number of studies have investigated the role of BCsin these diseases,the specific function of BCs as either epileptogenic or antiepileptic remains controversial.Therefore,we reviewed literatures on BCs,delved into the molecular mechanisms and signaling pathways,and updated theirprofile in several aspects.Firstly,BCs are heterogeneous and some of them show progenitor/stem cell character-istics.Secondly,BCs are relatively silent in electrophysiology but not completely isolated from their surroundings.Notably,abnormal mTOR signaling and aberrant immunogenic process have been observed within BCs-containingmalformations of cortical development(MCDs).The question whether BCs function as the evildoer or the defenderin BCs-containing MCDs is further discussed.Importantly,this review provides perspectives on future investigationsof the potential role of BCs in epilepsy.

关 键 词：Balloon cells MCD EPILEPSY mTOR pathway 

分 类 号：R742[医药卫生—神经病学与精神病学]