多酚Canolol生物活性研究进展  

Research progress on biological activity of polyphenol canolol

作　　者：马丛丛[1] 王雷 徐珍霞 倪犇 许继取[1] MA Congcong;WANG Lei;XU Zhenxia;NI Ben;XU Jiqu(Oil Crops Research Institute of Chinese Academy of Agriculture Sciences,Hubei Key Laboratory of Lipid Chemistry and Nutrition,Hubei Wuhan 430062,China)

机构地区：[1]中国农业科学院油料作物研究所,油料脂质化学与营养湖北省重点实验室,湖北武汉430062

出　　处：《食品工程》2024年第3期23-28,共6页Food Engineering

基　　金：国家自然科学基金(U21A20274);现代农业产业技术体系(CARS-12);中国农业科学院科技创新工程(CAAS-ASTIP-2016-OCRI)。

摘　　要：Canolol (4-vinyl-2,6-dimethoxyphenol)是菜籽油加工过程中产生的一种高效抗氧化剂,具有抗氧化、抗炎、抗癌、保护视网膜、保护心脏、降血糖、改善记忆力、抑菌等生物活性,其作用机制主要涉及环氧化合酶-2/前列腺素E2 (cyclooxygenase-2/prostaglandin E2,COX-2/PGE2)信号通路、磷酸肌醇-3激酶/蛋白激酶B (phosphoinositide 3-kinase/protein kinase B,PI3K/Akt)信号通路、活性氧/丝裂原活化蛋白激酶(reactive oxygen species/mitogen-activated protein kinase,ROS-MAPK)等信号通路和细胞外信号调节激酶(extracellular signal regulated kinase,ERK)级联。通过查阅国内外关于Canolol生物活性的相关文献,对其生物活性与作用机制进行分析,以期为Canolol在药品、食品、化妆品等领域的开发应用提供理论基础和参考。Canolol(4-vinyl-2,6-dimethoxyphenol)is a highly effective antioxidant produced during rapeseed oil processing,which has antioxidant,anti-inflammatory,anti-cancer,retinal protection,heart protection,hypoglycemia,memory improvement,antibacterial and other biological activities.The mechanism of canolol is mainly involved in Cyclooxygenase-2/prostaglandin E2(COX-2/PGE2)pathway,phosphoinositide 3-kinase/protein kinase B(PI3K/Akt)signaling pathway,reactive oxygen species/mitogen-activated protein kinase(ROS-MAPK)signaling pathways and extracellular signal regulated kinase(ERK)cascade.By referring to the domestic and foreign literatures on the biological activity of canolol,the biological activity and mechanism of action were analyzed,in order to provide theoretical basis and reference for the development and application of canolol in the fields of medicine,food,cosmetics and so on.

关 键 词：Canolol 抗氧化剂 生物活性 油菜籽 

分 类 号：TS225.16[轻工技术与工程—粮食、油脂及植物蛋白工程]