Age-related alveolar bone maladaptation in adult orthodontics:finding new ways out  

作　　者：Yunfan Zhang Jiale Yan Yuning Zhang Hao Liu Bing Han Weiran Li 

机构地区：[1]Department of Orthodontics,Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental Materials,Beijing,China

出　　处：《International Journal of Oral Science》2024年第3期398-412,共15页国际口腔科学杂志（英文版）

基　　金：supported by grants from the National Key R&D Program of China(2021YFC2400403);the National Natural Science Foundation of China(82201017,51972005);the Young Elite Scientist Sponsorship Program by CAST(2022QNRC001);the China Postdoctoral Science Foundation(2022M710257).

摘　　要：Compared with teenage patients,adult patients generally show a slower rate of tooth movement and more pronounced alveolar bone loss during orthodontic treatment,indicating the maladaptation of alveolar bone homeostasis under orthodontic force.However,this phenomenon is not well-elucidated to date,leading to increased treatment difficulties and unsatisfactory treatment outcomes in adult orthodontics.Aiming to provide a comprehensive knowledge and further inspire insightful understanding towards this issue,this review summarizes the current evidence and underlying mechanisms.The age-related abatements in mechanosensing and mechanotransduction in adult cells and periodontal tissue may contribute to retarded and unbalanced bone metabolism,thus hindering alveolar bone reconstruction during orthodontic treatment.To this end,periodontal surgery,physical and chemical cues are being developed to reactivate or rejuvenate the aging periodontium and restore the dynamic equilibrium of orthodontic-mediated alveolar bone metabolism.We anticipate that this review will present a general overview of the role that aging plays in orthodontic alveolar bone metabolism and shed new light on the prospective ways out of the impasse.

关 键 词：ALVEOLAR METABOLISM HOMEOSTASIS 

分 类 号：R783.5[医药卫生—口腔医学]