Molecular mechanisms underlying microglial sensing and phagocytosis in synaptic pruning  

作　　者：Anran Huo Jiali Wang Qi Li Mengqi Li Yuwan Qi Qiao Yin Weifeng Luo Jijun Shi Qifei Cong 

机构地区：[1]Clinical Research Center of Neurological Disease,The Second Affiliated Hospital of Soochow University,Institute of Neuroscience and Jiangsu Key Laboratory of Neuropsychiatric Diseases,Soochow University,Suzhou,Jiangsu Province,China [2]Department of Neurology and Clinical Research Center of Neurological Disease,The Second Affiliated Hospital of Soochow University,Suzhou,Jiangsu Province,China

出　　处：《Neural Regeneration Research》2024年第6期1284-1290,共7页中国神经再生研究（英文版）

基　　金：supported by the National Natural Science Foundation of China;No.32200778(to QC);the Natural Science Foundation of Jiangsu Province;No.BK20220494(to QC);Suzhou Medical and Health Technology Innovation Project;No.SKY2022107(to QC);a grant from the Clinical Research Center of Neurological Disease in The Second Affiliated Hospital of Soochow University;Nos.ND2022A04(to QC)and ND2023B06(to JS)。

摘　　要：Microglia are the main non-neuronal cells in the central nervous system that have important roles in brain development and functional connectivity of neural circuits.In brain physiology,highly dynamic microglial processes are facilitated to sense the surrounding environment and stimuli.Once the brain switches its functional states,microglia are recruited to specific sites to exert their immune functions,including the release of cytokines and phagocytosis of cellular debris.The crosstalk of microglia between neurons,neural stem cells,endothelial cells,oligodendrocytes,and astrocytes contributes to their functions in synapse pruning,neurogenesis,vascularization,myelination,and blood-brain barrier permeability.In this review,we highlight the neuron-derived“find-me,”“eat-me,”and“don't eat-me”molecular signals that drive microglia in response to changes in neuronal activity for synapse refinement during brain development.This review reveals the molecular mechanism of neuron-microglia interaction in synaptic pruning and presents novel ideas for the synaptic pruning of microglia in disease,thereby providing important clues for discovery of target drugs and development of nervous system disease treatment methods targeting synaptic dysfunction.

关 键 词：COMPLEMENT immune signals microglia molecular signal synapse elimination synapse formation synapse refinement synaptic pruning 

分 类 号：R741[医药卫生—神经病学与精神病学]