General anesthetic agents induce neurotoxicity through astrocytes  

作　　者：Yanchang Yang Tiantian Liu Jun Li Dandan Yan Yuhan Hu Pin Wu Fuquan Fang Patrick M.McQuillan Wenxin Hang Jianhang Leng Zhiyong Hu 

机构地区：[1]Department of Anesthesiology,The First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou,Zhejiang Province,China [2]Department of Anesthesiology,Ningbo Women and Children’s Hospital,Ningbo,Zhejiang Province,China [3]Department of Anesthesiology,Shulan(Hangzhou)Hospital Affiliated to Zhejiang Shuren University Shulan International Medical College,Hangzhou,Zhejiang Province,China [4]Cell Biology Department,Yale University,New Haven,CT,USA [5]Department of Anesthesiology,Penn State Hershey Medical Centre,Penn State College of Medicine,Hershey,PA,USA [6]Department of Central Laboratory,Affiliated Hangzhou First People’s Hospital,Zhejiang University School of Medicine,Hangzhou,Zhejiang Province,China

出　　处：《Neural Regeneration Research》2024年第6期1299-1307,共9页中国神经再生研究（英文版）

基　　金：supported by the National Natural Science Foundation of China,Nos.82171260,81641042,81471240;the Natural Science Foundation of Zhejiang Province,Nos.LZ22H090002 and 2014C33170(all to ZH)。

摘　　要：Neuroscientists have recognized the importance of astrocytes in regulating neurological function and their influence on the release of glial transmitters.Few studies,however,have focused on the effects of general anesthetic agents on neuroglia or astrocytes.Astrocytes can also be an important target of general anesthetic agents as they exert not only sedative,analgesic,and amnesic effects but also mediate general anesthetic-induced neurotoxicity and postoperative cognitive dysfunction.Here,we analyzed recent advances in understanding the mechanism of general anesthetic agents on astrocytes,and found that exposure to general anesthetic agents will destroy the morphology and proliferation of astrocytes,in addition to acting on the receptors on their surface,which not only affect Ca^(2+)signaling,inhibit the release of brain-derived neurotrophic factor and lactate from astrocytes,but are even involved in the regulation of the pro-and anti-inflammatory processes of astrocytes.These would obviously affect the communication between astrocytes as well as between astrocytes and neighboring neurons,other neuroglia,and vascular cells.In this review,we summarize how general anesthetic agents act on neurons via astrocytes,and explore potential mechanisms of action of general anesthetic agents on the nervous system.We hope that this review will provide a new direction for mitigating the neurotoxicity of general anesthetic agents.

关 键 词：ASTROCYTES brain-derived neurotrophic factor general anesthetic agents neuron NEUROTOXICITY N-methyl-D-aspartate receptor perioperative neurocognition Toll-like receptor γ-aminobutyric acid receptor 

分 类 号：R614[医药卫生—麻醉学]