Gastric metastasis of small cell lung carcinoma:A rare but noteworthy entity to consider  

作　　者：Cemal Ugur Dursun Ahmet Oguz Tugcu Galip Dogukan Dogru 

机构地区：[1]Department of Radiation Oncology,Kartal Dr.Lutfi Kirdar City Hospital,İstanbul 34865,Türkiye [2]Department of Radiation Oncology,Gulhane Training and Research Hospital,Ankara 06010,Türkiye

出　　处：《World Journal of Clinical Oncology》2024年第10期1379-1382,共4页世界临床肿瘤学杂志（英文）

摘　　要：Small cell lung carcinoma(SCLC)is an aggressive malignancy known for its propensity for early and extensive metastatic spread.Gastric metastasis,where cancer cells disseminate from the lung to the stomach,is a rare but increasingly recognized complication of SCLC.This review provides a comprehensive overview of gastric metastasis in SCLC,addressing its clinical significance,diagnostic challenges,management strategies,and prognosis.Additionally,it examines the broader metastatic patterns of SCLC and compares them with other malignancies known for gastric metastasis.Gastric metastasis in SCLC,though infrequent,is clinically significant and often indicates advanced disease with a poor prognosis.SCLC typically metastasizes to the liver,brain,bones,and adrenal glands,with the stomach being an unusual site.The incidence of gastric meta-stasis ranges from 1%to 5%in autopsy studies,although this may be underes-timated due to diagnostic difficulties and asymptomatic early lesions.Diagnosing gastric metastasis presents several challenges,including the asymptomatic nature of many cases,limitations of conventional imaging techniques,and difficulties in distinguishing metastatic lesions from primary gastric cancer via endoscopy.Histopathological diagnosis requires careful examination to identify SCLC cells through their characteristic small cell morphology and neuroendocrine markers.Management of gastric metastasis in SCLC typically involves a multidisciplinary approach.Systemic therapy,pri-marily chemotherapy,remains the cornerstone of treatment,with palliative care addressing symptoms and complications.Surgical intervention is usually reserved for specific cases requiring symptomatic relief.The prognosis for patients with gastric metastasis from SCLC is generally poor,reflecting the advanced stage of the disease.Median survival is significantly re-duced compared to patients without gastric metastasis.This review emphasizes the need for enhanced awareness and early detection to improve patient outcomes and highlights the imp

关 键 词：Lung cancer Small cell lung cancer Gastric metastasis METASTASIS Rare metastasis 

分 类 号：R734.2[医药卫生—肿瘤]