Evaluating genetic insights into ulcerative colitis and anxiety:Limitations and future directions  

作　　者：Ying Peng Xi-Dai Long 

机构地区：[1]Department of Pathology,The First Affiliated Hospital,Guangxi Medical University,Nanning 530021,Guangxi Zhuang Autonomous Region,China [2]Department of Pathology,Shenzhen Qianhai Shekou Free Trade Zone Hospital,Shenzhen 518000,Guangdong Province,China [3]Department of Pathology,The Affiliated Hospital of Youjiang Medical University for Nationalities,Baise 533000,Guangxi Zhuang Autonomous Region,China [4]Department of Liver Surgery,Ren Ji Hospital,School of Medicine,Shanghai Jiaotong University,Shanghai 200000,China

出　　处：《World Journal of Gastroenterology》2024年第37期4156-4159,共4页世界胃肠病学杂志（英文）

基　　金：Supported by Guangxi Training Program for Medical High-level Academic Leaders;Bose Talent Highland;Building Projects of Guangxi Bagui Scholars,No.Guirencaiban[2024]-39;Building Projects from the Key Laboratory of Molecular Pathology(Hepatobiliary Diseases)of Guangxi,the Key Laboratory of Tumor Molecular Pathology of Guangxi Colleges&Universities;Clinical Key Specialty Building Project(For Pathology)of Guangxi;and Nanshan District Health System Science and Technology Major Project,No.NSZD2024045.

摘　　要：We reviewed the study by He et al,which investigates the genetic correlation between ulcerative colitis(UC)and anxiety using bidirectional Mendelian rando-mization.This study reveals a genetic link between UC and anxiety,diverging from prior research associating higher anxiety with Crohn’s disease.While the study's use of large-scale genome-wide association studies data is commendable,it faces limitations such as single nucleotide polymorphism selection biases,lack of multiple testing corrections,and a reliance on European populations.Future research should address these limitations,incorporate diverse populations,and explore psychotherapeutic interventions to improve UC management and patient outcomes.

关 键 词：Ulcerative colitis ANXIETY Mendelian randomization Genome-wide association study Gut-brain axis Instrumental variables Genetic epidemiology PLEIOTROPY 

分 类 号：R574.62[医药卫生—消化系统]