PLEIOTROPY

作品数：25被引量：32H指数：3
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Evaluating genetic insights into ulcerative colitis and anxiety:Limitations and future directions
《World Journal of Gastroenterology》2024年第37期4156-4159,共4页Ying Peng Xi-Dai Long 
Supported by Guangxi Training Program for Medical High-level Academic Leaders;Bose Talent Highland;Building Projects of Guangxi Bagui Scholars,No.Guirencaiban[2024]-39;Building Projects from the Key Laboratory of Molecular Pathology(Hepatobiliary Diseases)of Guangxi,the Key Laboratory of Tumor Molecular Pathology of Guangxi Colleges&Universities;Clinical Key Specialty Building Project(For Pathology)of Guangxi;and Nanshan District Health System Science and Technology Major Project,No.NSZD2024045.
We reviewed the study by He et al,which investigates the genetic correlation between ulcerative colitis(UC)and anxiety using bidirectional Mendelian rando-mization.This study reveals a genetic link between UC and anxi...
关键词：Ulcerative colitis ANXIETY Mendelian randomization Genome-wide association study Gut-brain axis Instrumental variables Genetic epidemiology PLEIOTROPY 
Identification of susceptibility loci and relevant cell type for IgA nephropathy in Han Chinese by integrative genome-wide analysis
《Frontiers of Medicine》2024年第5期862-877,共16页Ming Li Xingjie Hao Dianchun Shi Shanshan Cheng Zhong Zhong Lu Cai Minghui Jiang Lin Ding Lanbo Ding Chaolong Wang Xueqing Yu 
supported by Guangdong-Hong Kong Joint Laboratory on Immunological and Genetic Kidney Diseases(No.2019B121205005);National Natural Science Foundation of China(Nos.81920108008,81770661,82170714,and 82003561);Guangzhou Municipal Science and Technology Project of China(No.202201011246);Basic and Applied Basic Research Foundation of Guangdong Province(No.2021A1515111054);Fundamental Research Funds for the Central Universities(No.2019kfyXJJS036).
Although many susceptibility loci for IgA nephropathy(IgAN)have been identified,they only account for 11.0%of the overall IgAN variance.We performed a large genome-wide meta-analysis of IgAN in Han Chinese with 3616 c...
关键词：IgA nephropathy(IgAN) genome-wide association study(GWAS) relevant cell types integrative analysis PLEIOTROPY 
Epistasis-aware genome-wide association studies provide insights into the efficient breeding of high-yield and high-quality rice
《Journal of Integrative Agriculture》2024年第8期2541-2556,共16页Xiaogang He Zirong Li Sicheng Guo Xingfei Zheng Chunhai Liu Zijie Liu Yongxin Li Zheming Yuan Lanzhi Li 
partially supported by the Science and Technology Innovation Program of Hunan Province,China(2023NK2001);the Hubei Key Laboratory of Food Crop Germplasm and Genetic Improvement,China(2022LZJJ08);the Special Funds for Construction of Innovative Provinces in Hunan Province,China(2021NK1011);the Natural Science Foundation of Hunan Province,China(2020JJ4039);the Key Research and Development Program of Hubei Province,China(2021BBA223)。
Marker-assisted selection(MAS)and genomic selection(GS)breeding have greatly improved the efficiency of rice breeding.Due to the influences of epistasis and gene pleiotropy,ensuring the actual breeding effect of MAS a...
关键词：rice genome-wide association study EPISTASIS gene pleiotropy maker-associated selection genome selection 
Evolutionary history and biological adaptation of Han Chinese people on the Mongolian Plateau被引量：2
《hLife》2024年第6期296-313,共18页Xiangping Li Mengge Wang Haoran Su Shuhan Duan Yuntao Sun Hongyu Chen Zhiyong Wang Qiuxia Sun Qingxin Yang Jing Chen Ting Yang Yuguo Huang Jie Zhong Xiucheng Jiang Jinyue Ma Shijia Chen Yunhui Liu Lintao Luo Xinyu Lin Shengjie Nie Chao Liu Liping Hu Guanglin He 
We thank all the volunteers who participated in this project and the researchers who provided help and support for this project(Prof.Etienne Patin and Prof.Lluis Quintana-Murci from the Human Evolutionary Genetics Unit of the Institute Pasteur;Prof.Mark Stoneking and Prof.Dang Liu from the Max Planck Institute for Evolutionary Anthropology;and Prof.Wibhu Kutanan from Khon Kaen University).We are indebted to Grammarly(https://app.grammarly.com/)for its invaluable contribution to the linguistic refinement and readability enhancement of this manuscript.M.W.is supported by the National Natural Science Foundation of China(82202078);G.H.is supported by the Major Project of the National Social Science Foundation of China(23&ZD203);the Open Project of the Key Laboratory of Forensic Genetics of the Ministry of Public Security(2022FGKFKT05);the Center for Archaeological Science of Sichuan University(23SASA01);the 1.3.5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(ZYJC20002);the Sichuan Science and Technology Program.L.H.is supported by the Open Project of Shanghai Key Laboratory of Forensic Medicine(KF202309).
Complex demographic processes and natural selection pressures are critical to resolving patterns of the molecular genetic basis of adaptive traits or complex diseases.Recent ancient genome data allow us to trace how k...
关键词：demographic history biological adaptation polygenicity and pleiotropy metabolic fitness 
Systematic Exploration of Optimized Base Editing gRNA Design and Pleiotropic Effects with BExplorer
《Genomics, Proteomics & Bioinformatics》2023年第6期1237-1245,共9页Gongchen Zhang Chenyu Zhu Xiaohan Chen Jifang Yan Dongyu Xue Zixuan Wei Guohui Chuai Qi Liu 
supported by the National Key R&D Program of China(Grant No.2021YFF1201200);the National Natural Science Foundation of China(Grant Nos.31970638 and 61572361);the Shanghai Natural Science Foundation Program(Grant No.17ZR1449400);the Shanghai Artificial Intelligence Technology Standard Project(Grant No.19DZ2200900);the Shanghai Shuguang scholars project,the WeBank scholars project,and the Fundamental Research Funds for the Central Universities.
Base editing technology is being increasingly applied in genome engineering,but the current strategy for designing guide RNAs(gRNAs)relies substantially on empirical experience rather than a dependable and efficient i...
关键词：Gene editing Base editing PLEIOTROPY CRISPR/Cas9 gRNAdesign 
Pleiotropy Structures Plant Height and Seed Weight Scaling in Barley despite Long History of Domestication and Breeding Selection
《Plant Phenomics》2023年第1期85-93,共9页Tianhua He Tefera Tolera Angessa Chengdao Li 
supported by the Australian Grain Research and Development Corporation(UMU00049).
Size scaling describes the relative growth rates of different body parts of an organism following a positive correlation.Domestication and crop breeding often target the scaling traits in the opposite directions.The g...
关键词：BREEDING SCALING Plant 
A novel and powerful approach for designing future crops—target editing promoter overcomes tradeoffs caused by gene pleiotropy
《Science China(Life Sciences)》2022年第10期2128-2130,共3页Qingqing Hou Jing Wang Xuewei Chen 
Over the past decades,crop breeding has undergone genetic improvement through semi-dwarfness,heterosis,and ideal plant architecture,which increases yield tremendously to feed the growing population worldwide.However,c...
关键词：breeding CROPS DWARF 
Genetic Pleiotropy Test by Quasi p-Value with Application to Typhoon Data in China被引量：1
《Journal of Systems Science & Complexity》2022年第4期1557-1572,共16页WU Qiang ZHONG Shaojun TONG Xingwei 
supported by National Key Research and Development Program of China under Grant No.2017YFA0604903;the National Natural Science Foundation of China under Grant No.11971064;the Ph.D.start-up fund of Hubei University of Science and Technology under Grant No.BK201813。
To test genetic pleiotropy,the main difficulty lies in the failure to find a test statistic and calculate its p-value for determining whether to reject the null hypothesis or not.To deal with this issue,the authors pr...
关键词：Bayesian rule data-driven EM algorithm genetic pleiotropy quasi p-value 
Diabetes mellitus susceptibility with varied diseased phenotypes and its comparison with phenome interactome networks
《World Journal of Clinical Cases》2022年第18期5957-5964,共8页Madhusmita Rout Bhumandeep Kour Sugunakar Vuree Sajitha S Lulu Krishna Mohan Medicherla Prashanth Suravajhala 
An emerging area of interest in understanding disease phenotypes is systems genomics.Complex diseases such as diabetes have played an important role towards understanding the susceptible genes and mutations.A wide num...
关键词：Type 1 diabetes Gestational diabetes mellitus Prostate cancer Phenome Type 2 diabetes PLEIOTROPY 
Two macrophages, osteoclasts and microglia: from development to pleiotropy被引量：4
《Bone Research》2021年第2期143-152,共10页Ji-Won Lee In-Hee Lee Tadahiro Iimura Sek Won Kong 
supported by the grants from the National Institution of Health(R01MH107205,R24OD024622,and U01TR002623);supported by Grantin-Aids for Scientific Research from the Japan Society for the Promotion of Science(19K10044).
Tissue-resident macrophages are highly specialized to their tissue-specific microenvironments,activated by various inflammatory signals and modulated by genetic and environmental factors.Osteoclasts and microglia are ...
关键词：diagnosis OSTEOPOROSIS OSTEOCLAST 
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