Journey to diagnosis:An unfinished exploration of IgG4-related sclerosing cholangitis  

作　　者：Ming-Xing Liang Ya Chen Ya He Yi-Huai He 

机构地区：[1]Department of Infectious Diseases,Affiliated Hospital of Zunyi Medical University,Zunyi 563000,Guizhou Province,China

出　　处：《World Journal of Clinical Cases》2024年第33期6608-6612,共5页世界临床病例杂志（英文）

基　　金：Supported by The Science and Technology Research Foundation of Guizhou Province,and Zunyi City,No.QKHJC-ZK(2022)YB642,No.ZSKH·HZ(2022)344,and No.gzwjkj2021-071;The WBE Liver Fibrosis Foundation,No.CFHPC2025028;The Beijing Gandan Phase Mutual Public Welfare Fund for Artificial Liver Project,No.iGandanF-1082024-Rgg018.

摘　　要：IgG4-related sclerosing cholangitis(IgG4-SC)is an inflammatory disease that leads to bile duct stricture,characterized by the infiltration of IgG4-positive plasma cells into the bile duct wall,thickening of the bile duct wall,and narrowing of the lumen.The differential diagnosis of IgG4-SC mainly includes primary sclerosing cholangitis,cholangiocarcinoma,and pancreatic cancer.IgG4-SC is often associated with autoimmune pancreatitis and can be accurately diagnosed based on clinical diagnostic criteria.However,isolated IgG4-SC is difficult to distinguish from biliary tumors.Given the significant differences in biological behavior,treatment,and prognosis between these diseases,accurately identifying isolated IgG4-SC has very important clinical significance.

关 键 词：Isolated IgG4-associated sclerosing cholangitis CHOLANGIOCARCINOMA Autoimmune pancreatitis IgG4-related diseases Diagnosis and differential diagnosis 

分 类 号：R575.7[医药卫生—消化系统]