Is Helicobacter pylori infection protective against esophageal cancer?  

作　　者：Rick Maity Arkadeep Dhali Jyotirmoy Biswas 

机构地区：[1]General Medicine,Institute of Post Graduate Medical Education and Research,Kolkata 700020,India [2]Department of Gastroenterology,Sheffield Teaching Hospitals NHS Foundation Trust,Royal Hallamshire Hospital,Sheffield S102JF,United Kingdom [3]School of Medicine and Population Health,University of Sheffield,Sheffield S102HQ,United Kingdom [4]Deanery of Clinical Sciences,University of Edinburgh,Edinburgh EH164SB,United Kingdom [5]Department of General Medicine,College of Medicine and Sagore Dutta Hospital,Kolkata 700058,India

出　　处：《World Journal of Gastroenterology》2024年第38期4168-4174,共7页世界胃肠病学杂志（英文）

摘　　要：Helicobacter pylori(H.pylori)infection affects a substantial proportion of the global population and causes various gastric disorders,including gastric cancer.Recent studies have found an inverse relationship between H.pylori infection and eso-phageal cancer(EC),suggesting a protective role against EC.This editorial focuses on the possible mechanisms underlying the role of H.pylori infection in EC and explores the role of gut microbiota in esophageal carcinogenesis and the prac-ticality of H.pylori eradication.EC has two major subtypes:Esophageal squamous cell carcinoma(ESCC)and esophageal adenocarcinoma(EAC),which have different etiologies and risk factors.Gut microbiota can contribute to EC via inflammation-induced carcinogenesis,immunomodulation,lactagenesis,and genotoxin production.H.pylori infection is said to be inversely related to EAC,protecting against EAC by inducing atrophic gastritis,altering serum ghrelin levels,and triggering cancer cell apoptosis.Though H.pylori infection has no significant association with ESCC,COX-2-1195 polymorphisms and endogenous nitrosamine production can impact the risk of ESCC in H.pylori-infected in-dividuals.There are concerns regarding a plausible increase in EC after H.pylori eradication treatments.However,H.pylori eradication is not associated with an increased risk of EC,making it safe from an EC perspective.

关 键 词：Helicobacter pylori Helicobacter pylori infection Esophageal cancer Esophageal squamous cell carcinoma Esophageal adenocarcinoma Barrett’s esophagus MICROBIOTA DYSBIOSIS ERADICATION 

分 类 号：R735.1[医药卫生—肿瘤]