Survival outcomes in early-onset oesophageal adenocarcinoma patients:A systematic review and meta-analyses  

作　　者：Ashleigh Russell Shauna Mitchell Richard C Turkington Helen G Coleman 

机构地区：[1]Centre for Public Health,Queen's University Belfast,Belfast BT126BA,United Kingdom [2]Patrick G Johnston Centre for Cancer Research,Queen's University Belfast,Belfast BT71NN,United Kingdom

出　　处：《World Journal of Gastroenterology》2024年第38期4221-4231,共11页世界胃肠病学杂志（英文）

摘　　要：BACKGROUND The incidence of oesophageal adenocarcinoma(OAC)has been reported to be increasing in many countries.Alongside this trend,an increase in incidence of early-onset OAC,defined as OAC in adults aged under 50 years,has been observed.It is unclear whether survival outcomes for early-onset OAC patients differ from older age groups.AIM To investigate survival outcomes in early-onset OAC patients.METHODS Ovid Medline and Embase were searched from inception to January 2022 for relevant studies relating to early-onset OAC and survival outcomes.Results regarding the overall five-year survival and risk of death of younger and older patients with OAC were extracted and pooled using meta-analyses to produce pooled estimates and 95%CIs where possible.RESULTS Eleven studies which compared survival of early-onset OAC,defined as age at diagnosis of<50 years,with older patients were included.A narrative review of median and mean survival demonstrated conflicting results,with studies showing early-onset OAC patients having both better and worse outcomes compared to older age groups.A meta-analysis of five-year survival demonstrated similar outcomes across age groups,with 22%-25%of patients in the young,middle and older age groups alive after five years.A meta-analysis of four studies demon-strated that early-onset OAC patients did not have a significantly increased risk of death compared to middle-aged patients(hazard ratio 1.12,95%CI:0.85-1.47).INTRODUCTION There is concern that the incidence of oesophageal adenocarcinoma(OAC)in patients under 50,described as early-onset OAC,is increasing.However,data regarding survival of younger patients with OAC is sparse.Globally,while increasing age remains a major non-modifiable risk factor for cancer,the incidence of early-onset cancers,largely accepted to be in adults aged under 50 years,is increasing[1].This includes an observed increase in the incidence of gastrointestinal malignancies such as colorectal,oesophageal,gastric and hepatobiliary cancers[2-4].Despite oesophageal squ

关 键 词：Early-onset cancer Early-onset oesophageal adenocarcinoma SURVIVAL Cancer epidemiology Systematic review META-ANALYSIS 

分 类 号：R735.1[医药卫生—肿瘤]