Impact of liver metastasis on immunotherapy in gastric carcinoma  

作　　者：Mushtaq Chalkoo Mohd Yaqoob Bhat Yaser Hussain Wani 

机构地区：[1]Department of Surgery,Government Medical College,Srinagar 190014,Jammu and Kashmir,India [2]Department of General Surgery,Government Medical College Srinagar,Srinagar 190010,Jammu and Kashmir,India [3]Post Graduate Department of Minimal Access and General Surgery,Government Medical College Srinagar,Srinagar 190010,Jammu and Kashmīr,India

出　　处：《World Journal of Gastrointestinal Surgery》2024年第10期3084-3086,共3页世界胃肠外科杂志（英文）

摘　　要：The editorial discusses the impact of liver metastasis on immunotherapy efficacy in gastric cancer(GC)patients.Liver metastasis can hinder the effectiveness of immunotherapy by altering the immune microenvironment,leading to systemic loss of T-cells and reduced treatment response.Studies suggest that liver meta-stases serve as a negative baseline factor for immunotherapy efficacy,resulting in poorer progression-free survival and objective response rates.Strategies such as liver-mediated radiotherapy may help improve treatment outcomes by reshaping the liver’s immune microenvironment and reducing T-cell depletion.Understand-ing the complex interplay between liver metastasis and immunotherapy response is crucial for optimising patient care in GC.

关 键 词：IMMUNOTHERAPY Liver metastasis Immune tolerance Gastric carcinoma Hepatic Siphoning 

分 类 号：R735.7[医药卫生—肿瘤]