Relationship between serum neutrophil gelatinase-associated lipocalin levels and cognitive impairment, anxiety, and depressive symptoms in acute ischemic stroke  

作　　者：You-Quan Gu Xuan Zhou Li-He Yao Qiang Wang Chao-Ning Zhou Zhao-Dong Liu 

机构地区：[1]Department of Neurology,The First Hospital of Lanzhou University,Lanzhou 730000,Gansu Province,China [2]Department of Neurology,The First Clinical Medical College of Lanzhou University,Lanzhou 730099,Gansu Province,China

出　　处：《World Journal of Psychiatry》2024年第10期1467-1473,共7页世界精神病学杂志（英文）

基　　金：Supported by Gansu Provincial Natural Science Foundation,No.20JR10RA671;and The Fund of the First Hospital of Lanzhou University,No.ldyyyn2021-103.

摘　　要：BACKGROUND Acute ischemic stroke(AIS)is a significant global health issue with increasing incidence owing to aging populations and rising cardiovascular risk factors.In addition to physical impairments,AIS frequently leads to neuropsychiatric co-mplications,such as cognitive impairment,anxiety,and depressive symptoms,which adversely affect patients’quality of life and rehabilitation.Neutrophil ge-latinase-associated lipocalin(NGAL)has emerged as a potential biomarker for various conditions,including AIS.This study investigated the association bet-ween serum NGAL levels at admission and neuropsychiatric complications in patients with AIS.neuropsychiatric complications in patients with AIS.METHODS Between January 2022 and December 2023,150 patients with AIS were enrolled.Serum NGAL levels were measured at admission using an enzyme-linked immu-nosorbent assay.Cognitive function was assessed using the Mini-Mental State Examination,while anxiety and depressive symptoms were evaluated using the Hospital Anxiety and Depression Scale at discharge.The relationship between serum NGAL levels and cognitive impairment,anxiety,and depressive symptoms was analyzed using multivariate logistic regression,adjusted for potential con-founders of age,sex,body mass index,smoking status,hypertension,diabetes mellitus,dyslipidemia,previous stroke,and stroke severity.RESULTS The mean age of the participants was 65.4±10.2 years,and 58%were males.Prevalence rates of cognitive impairment,anxiety,and depressive symptoms at discharge were 34.7%,28.0%,and 32.0%,respectively.Serum NGAL levels were significantly higher in patients with cognitive impairment(median:5.6 ng/mL vs 3.2 ng/mL,P<0.001),anxiety(median:5.1 ng/mL vs 3.5 ng/mL,P=0.002),and depressive symptoms(median:5.4 ng/mL vs 3.3 ng/mL,P<0.001),compared to those without these conditions.Multivariate logistic regression analysis showed that higher serum NGAL levels at admission were independently associated with cognitive impairment[odds ratio(OR)=1.42,95%confidence interval(CI):1.18-1

关 键 词：Neutrophil gelatinase-associated lipocalin Neuropsychiatric complications BIOMARKER Acute ischemic stroke Cognitive impairment ANXIETY Depressive symptoms 

分 类 号：R749.4[医药卫生—神经病学与精神病学]