Co-culture models for investigating cellular crosstalk in the glioma microenvironment  

作　　者：Xiaodong Niu Yan Zhang Yuan Wang 

机构地区：[1]Department of Neurosurgery,State Key Laboratory of Biotherapy and Cancer Center,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China [2]National Clinical Research Center for Geriatrics,State Key Laboratory of Biotherapy and Cancer Center,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China

出　　处：《Cancer Pathogenesis and Therapy》2024年第4期219-230,共12页癌症发生与治疗（英文）

摘　　要：Glioma is the most prevalent primary malignant tumor in the central nervous system(CNS).It represents a diverse group of brain malignancies characterized by the presence of various cancer cell types as well as an array of noncancerous cells,which together form the intricate glioma tumor microenvironment(TME).Understanding the interactions between glioma cells/glioma stem cells(GSCs)and these noncancerous cells is crucial for exploring the pathogenesis and development of glioma.To invesigate these interactions requires in vitro co-culture models that closely mirror the actual TME in vivo.In this review,we summarize the two-and three-dimensional in vitro coculture model systems for glioma-TME interactions currently available.Furthermore,we explore common gliomaTME cell interactions based on these models,including interactions of glioma cells/GSCs with endothelial cells/pericytes,microglia/macrophages,T cells,astrocytes,neurons,or other multi-cellular interactions.Together,this review provides an update on the glioma-TME interactions,offering insights into glioma pathogenesis.

关 键 词：GLIOMA Coculture techniques Tumor microenvironment 

分 类 号：R739.41[医药卫生—肿瘤]