Autophagy as a targeted therapeutic approach for skin cancer:Evaluating natural and synthetic molecular interventions  

作　　者：Md.Liakot Ali Amdad Hossain Roky S.M.Asadul Karim Azad Abdul Halim Shaikat Jannatul Naima Meem Emtiajul Hoque Abu Mohammed Fuad Ahasan Mohammed Murshedul Islam Md.Saifur Rahaman Arif Md.Saqline Mostaq Md.Zihad Mahmud Mohammad Nurul Amin MdAshiq Mahmud 

机构地区：[1]Department of Pharmacy,University of Chittagong,Chattogram 4331,Bangladesh [2]Pratyasha Health Biomedical Research Center,Dhaka 1230,Bangladesh [3]Department of Pharmacy,International Islamic University Chittagong,Chattogram 4318,Bangladesh [4]Department of Pharmacy,Daffodil International University,Dhaka 1216,Bangladesh [5]Department of Pharmacy,BGC Trust University Bangladesh,Chattogram 4381,Bangladesh [6]School of Basic Pharmaceutical and Toxicological Sciences,College of Pharmacy,University of Louisiana at Monroe,Monroe,LA 71209-0497,USA [7]Pioneer Dental College and Hospital,Dhaka 1229,Bangladesh

出　　处：《Cancer Pathogenesis and Therapy》2024年第4期231-245,共15页癌症发生与治疗（英文）

摘　　要：Skin cancer,a prevalent malignancy worldwide,poses significant health concerns owing to its increasing incidence.Autophagy,a natural cellular process,is a pivotal event in skin cancer and has advantageous and detrimental effects.This duality has prompted extensive investigations into medical interventions targeting autophagy modulation for their substantial therapeutic potential.This systematic review aimed to investigate the relationship between skin cancer and autophagy and the contribution and mechanism of autophagy modulators in skin cancer.We outlined the effectiveness and safety of targeting autophagy as a promising therapeutic strategy for the treatment of skin cancer.This comprehensive review identified a diverse array of autophagy modulators with promising potential for the treatment of skin cancer.Each of these compounds demonstrates efficacy through distinct physiological mechanisms that have been elucidated in detail.Interestingly,findings from a literature search indicated that none of the natural,synthetic,or semisynthetic compounds exhibited notable adverse effects in either human or animal models.Consequently,this review offers novel mechanistic and therapeutic perspectives on the targeted modulation of autophagy in skin cancer.

关 键 词：AUTOPHAGY Skin cancer Autophagy inducers Autophagy inhibitors Nature-derived compounds Synthetic compounds 

分 类 号：R739.5[医药卫生—肿瘤]