皮脂腺衰老的表现及发生机制研究进展  

Manifestations and pathogenesis of the sebaceous gland aging

作　　者：郑思齐 程淑琼 钟美珍 郑跃 黄晓雯 ZHENG Siqi;CHEN Shuqiong;ZHONG Meizhen;ZHENG Yue;HUANG Xiaowen(Nanfang Hospital,Southern Medical University,Guangzhou 510515,China)

机构地区：[1]南方医科大学南方医院,广东广州510515

出　　处：《皮肤性病诊疗学杂志》2024年第9期634-642,共9页Journal of Diagnosis and Therapy on Dermato-venereology

摘　　要：皮脂腺衰老通常始于曝光区域,表现为皮脂腺增生和脂质失调,进而导致皮肤干燥、缺乏光泽,促进菌群改变、色素沉着及皮肤疾病发生。在内源性及外源性因素作用下,皮脂腺导管发生扩张、脂质分泌减少、腺体增生并产生炎性浸润。介导皮脂腺衰老的下游机制包括ROS、自噬、Wnt信号通路、线粒体功能不良等。抗氧化、益生菌、光电疗法、外泌体对延缓皮脂腺衰老具有积极意义。本文从皮脂腺衰老的表现出发,阐述其内在的发生机制研究进展及应对措施。Aging in the sebaceous glands typically begins on the sun-exposed areas,characterized by sebaceous gland hyperplasia and lipid dysbiosis.These changes result in dry and dull skin,alterations in the microbiota,pigmentation,and various skin diseases.Both intrinsic and extrinsic factors contribute to this process,causing dilation of sebaceous ducts,reducing lipid secretion,promoting gland proliferation,and inducing inflammation.Key downstream mechanisms driving sebaceous gland aging include reactive oxygen species(ROS),autophagy,the Wnt signaling pathway,and mitochondrial dysfunction.Interventions such as antioxidants,probiotics,phototherapy,and exosomes can delay the sebaceous gland aging.This article will discuss the manifestations of the sebaceous gland aging,elucidate its underlying mechanisms,review current research progress,and explore potential countermeasures.

关 键 词：皮脂腺衰老 皮脂腺 线粒体疾病 自噬 微生物群 外泌体 

分 类 号：R758.73[医药卫生—皮肤病学与性病学]