Alterations in Serum Lipids and Lipoproteins Induced by Neoadjuvant Chemotherapy in Patients with Osteosarcoma around the Knee Joint:A Retrospective Analysis  

作　　者：Su-guo WANG Yong-gang WANG Guo-wei QIAN Li-na TANG Xin ZHOU Dong-dong CHENG Chen-liang ZHOU Qing-cheng YANG Zan SHEN Gao-zhong HUANG Hong-tao LI 

机构地区：[1]Department of General Medicine,Shenzhen Third People's Hospital,Shenzhen 518112,China [2]Department of VIP Clinic,Shanghai Jiao Tong University Afiliated Sixth People's Hospital,Shanghai 200233,China [3]Department of Oncology,Shanghai Jiao Tong University Affiliated Sixth People's Hospital,Shanghai 200233,China [4]Cancer Research Institute of Jilin University,the First Hospital of Jilin University,Changchun 130021,China [5]Department of Orthopedics,Shanghai Jiao Tong University Afiliated Sixth People's Hospital,Shanghai 200233,China

出　　处：《Current Medical Science》2024年第4期741-747,共7页当代医学科学（英文）

基　　金：supported by China Medicine Education Association(CMEA)(No.2020KTS012);the National Natural Science Foundation of China(NSFC)(No.82002962 and No.81900189).

摘　　要：Objective To investigate the serum lipid profiles of patients with localized osteosarcoma around the knee joint before and after neoadjuvant chemotherapy.Methods After retrospectively screening the data of 742 patients between January 2007 and July 2020,50 patients aged 13 to 39 years with Enneking stage II disease were included in the study.Serum lipid levels,including total cholesterol(TC),triglycerides(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),lipoprotein-α[Lp(a)],and apolipoprotein A1,B,and E(ApoA1,ApoB,and ApoE),and clinicopathological characteristics were collected before and after neoadjuvant chemotherapy.Results The mean levels of TC,TG,and ApoB were significantly increased following neoadjuvant chemotherapy(16%,38%,and 20%,respectively,vs.pretreatment values;P<0.01).The mean levels of LDL-C and ApoE were also 19%and 16%higher,respectively(P<0.05).No correlation was found between the pretreatment lipid profile and the histologic response to chemotherapy.An increase in Lp(a)was strongly correlated with the Ki-67 index(R=0.31,P=0.023).Moreover,a trend toward longer disease-free survival(DFS)was observed in patients with decreased TG and increased LDL-C following chemotherapy,although this difference was not statistically significant(P=0.23 and P=0.24,respectively).Conclusion Significant elevations in serum lipids were observed after neoadjuvant chemotherapy in patients with localized osteosarcoma.There was no prognostic significance of pretreatment serum lipid levels on histologic response to neoadjuvant chemotherapy.The scale of increase in serum Lp(a)might have a potential prognostic role in osteosarcoma.Patients with increased LDL-C or reduced TG after chemotherapy seem to exhibit a trend toward favorable DFS.

关 键 词：OSTEOSARCOMA neoadjuvant chemotherapy serum lipids 

分 类 号：R73[医药卫生—肿瘤]