Comparative associations of non-alcoholic fatty liver disease and metabolic dysfunction-associated steatotic liver disease with risk of incident chronic kidney disease:a cohort study  

作　　者：Ji Hye Heo Mi Yeon Lee Seong Hwan Kim Ming-Hua Zheng Christopher D.Byrne Giovanni Targher Ki-Chul Sung 

机构地区：[1]Department of Internal Medicine,Hallym University College of Medicine,Chuncheon,Republic of Korea [2]Division of Biostatistics,Department of R&D Management,Kangbuk Samsung Hospital,Sungkyunkwan University School of Medicine,Seoul,Republic of Korea [3]Division of Cardiology,Department of Internal Medicine,Korea University Ansan Hospital,Ansan,Republic of Korea [4]MAFLD Research Center,Department of Hepatology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China [5]Wenzhou Key Laboratory of Hepatology,Wenzhou,China [6]Institute of Hepatology,Wenzhou Medical University,Wenzhou,China [7]Key Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang Province,Wenzhou,China [8]Nutrition and Metabolism,Faculty of Medicine,University of Southampton,Southampton,UK [9]Southampton National Institute for Health and Care Research,Biomedical Research Centre,University Hospital Southampton,Southampton,UK [10]Metabolic Diseases Research Unit,IRCCS Sacro Cuore-Don Calabria Hospital,Negrar di Valpolicelle,Italy [11]Division of Cardiology,Department of Internal Medicine,Kangbuk Samsung Hospital,Sungkyunkwan University School of Medicine,Seoul,Republic of Korea

出　　处：《Hepatobiliary Surgery and Nutrition》2024年第5期801-813,I0003-I0005,共16页肝胆外科与营养（英文）

摘　　要：Background:We examined the comparative associations between non-alcoholic fatty liver disease(NAFLD)and metabolic dysfunction-associated steatotic liver disease(MASLD)definitions with risk of developing chronic kidney disease(CKD)and abnormal albuminuria.Methods:We conducted a cohort study of 214,145 Korean adults with normal kidney function at baseline who underwent liver ultrasonography.Participants were further subdivided into no steatotic liver disease(no-SLD),NAFLD-only,MASLD-only,both NAFLD and MASLD,and SLD not categorized as NAFLD or MASLD groups.Cox proportional hazards models were used to analyze the risk of incident CKD and albuminuria.Results:Compared with either the no-NAFLD or no-MASLD groups,the NAFLD and MASLD groups were associated with a higher risk of incident CKD(NAFLD:adjusted hazard ratio(HR),1.18[95%CI,1.01-1.38];MASLD:adjusted HR,1.21[95%CI,1.04-1.39]).Among the five subgroups,both NAFLD and MASLD group had the strongest association with risk of incident CKD(adjusted HR,1.21[95%CI,1.04-1.42]).The MASLD-only group had the strongest association with incident abnormal albuminuria,with an adjusted HR comparable to that of the both NAFLD and MASLD group(adjusted HR 1.96[95%CI,1.44-2.67]for the MASLD-only,and adjusted HR 1.98[95%CI,1.58-2.49]for the both NAFLD and MASLD group versus the no-SLD group).The NAFLD-only group was not independently associated with risk of CKD or abnormal albuminuria.Conclusions:These findings suggest that MASLD definition identifies individuals at high risk of developing incident CKD or abnormal albuminuria better than NAFLD definition.

关 键 词：Metabolic dysregulation non-alcoholic fatty liver disease(NAFLD) metabolic syndrome chronic kidney disease(CKD) ALBUMINURIA 

分 类 号：R575.5[医药卫生—消化系统]