Existing and emerging biomarkers in hepatocellular carcinoma:relevance in staging,determination of minimal residual disease,and monitoring treatment response:a narrative review  

作　　者：Dana A.Dominguez Paul Wong Laleh G.Melstrom 

机构地区：[1]Department of Surgical Oncology,City of Hope National Medical Center,Duarte,CA,USA [2]University of California,San Francisco,San Francisco,CA,USA

出　　处：《Hepatobiliary Surgery and Nutrition》2024年第1期39-55,共17页肝胆外科与营养（英文）

摘　　要：Background and Objective:With the development of novel active systemic therapies,the landscape of hepatocellular carcinoma(HCC)management is rapidly changing.However,HCC lacks sensitive and specific biomarkers to predict prognosis,monitor for minimal residual disease after locoregional therapy,and predict treatment response.In this review,we aim to summarize the best supporting evidence for refining existing,and development of novel biomarkers for staging,prognosis,determination of minimal residual disease and monitoring treatment response in HCC,focusing on those with evidence in clinical trials.Methods:PubMed and Embase databases were searched using the keywords;hepatocellular carcinoma,biomarker,minimal residual disease,surveillance,prognosis,staging,alpha-fetoprotein(AFP),liquid biopsy,treatment response,adjuvant,immunotherapy.Relevant clinical studies were included.Key Content and Findings:AFP remains the major workhorse as the most widely used biomarker in HCC,however,its lack of wide applicability due to the high proportion of patients with HCC who are AFP negative,limits its value throughout all stages of HCC management.Significant work has been done to combine AFP with other clinical and serologic factors to increase its accuracy and utility as a biomarkers.However,it is likely that other more novel biomarkers such as those obtained through liquid biopsy will provide the prognostic power necessary for applications such as detecting recurrence and predicting treatment response.Liquid biopsy provides not only a wealth of potential biomarkers including circulating tumor cells and cell-free RNA/DNA,but also the ability to examine the mutational characteristics of the tumor with next generation sequencing.While early evidence supports the potential impact of many new biomarkers,validation in large clinical trials is lacking.Conclusions:This review highlights the paucity of sensitive and specific,widely applicable biomarkers,throughout all phases of management of HCC and summarizes evidence on biomarkers curre

关 键 词：Hepatocellular carcinoma(HCC) BIOMARKER liquid biopsy alpha-fetoprotein(AFP) 

分 类 号：R735.7[医药卫生—肿瘤]