Prognostic value of para-aortic lymph node metastasis and dissection for pancreatic head ductal adenocarcinoma: a retrospective cohort study  

作　　者：Yecheng Xu Feng Yang Deliang Fu 

机构地区：[1]Department of Pancreatic Surgery,Huashan Hospital,Fudan University,Shanghai 200040,China

出　　处：《Journal of Pancreatology》2024年第3期199-206,共8页胰腺病学杂志（英文）

摘　　要：Background:Para-aortic lymph node(PALN)metastasis affects approximately 20%of patients with pancreatic ductal adenocarcinoma(PDAC).However,the prognostic significance of PALN metastases and dissection remains unclear.Methods:This retrospective cohort study included patients with PDAC of the pancreatic head who had undergone pancreaticoduodenectomy(PD)at our center between January 2017 and December 2020.Results:A total of 234 patients were included in the study.PALN dissection improved the median overall survival(OS)without statistical significance(24.1 vs 18.1 months,P=.156).The median recurrence-free survival was significantly longer in the PALN-dissection group than the group without PALN dissection(18.2 vs 11.6 months,P=.040).Conversely,there were no significant differences in the long-term prognosis between the PALN-positive and PALN-negative subgroups in the PALN-dissection group.Multivariate analysis showed that PALN metastasis was not an independent risk factor for OS(hazard ratio:0.831,95%confidence interval:0.538–1.285,P=.406).Conclusions:For patients with pancreatic head ductal adenocarcinoma,PD with PALN dissection may achieve survival prolongation and bridge the survival gap between patients with and without PALN metastasis without significantly increasing the perioperative risks.

关 键 词：Pancreatic ductal adenocarcinoma PANCREATICODUODENECTOMY Para-aortic lymph node SURVIVAL Textbook outcome 

分 类 号：R735.9[医药卫生—肿瘤]