身体质量指数与常见泌尿系肿瘤的因果关系:一项两样本孟德尔随机化研究  

Causal relationship between constitutional index and urinary tumors:a two-sample Mendelian randomization study

作　　者：吴明 邵晋凯[2] 柴红强 庞磊[2] WU Ming;SHAO Jinkai;CHAI Hongqiang;PANG Lei(The Fifth Clinical Medical College of Shanxi Medical University,Taiyuan 030012;Department of Urology,Shanxi Provincial People's Hospital,Taiyuan 030012,China)

机构地区：[1]山西医科大学第五临床医学院,山西太原030012 [2]山西省人民医院泌尿外科,山西太原030012

出　　处：《现代泌尿外科杂志》2024年第10期898-902,共5页Journal of Modern Urology

摘　　要：目的采用两样本孟德尔随机化方法探究身体质量指数(BMI)与常见泌尿系肿瘤发病风险之间的因果关系。方法筛选IEU公共数据库中的BMI全基因组关联分析数据和肾癌、前列腺癌、膀胱癌的全基因组关联分析数据,通过逆方差加权法(IVW)、MR-Egger回归分析、加权中位数分析等两样本孟德尔随机化方法来评估BMI与上述3种泌尿系肿瘤之间可能存在的因果关系。最后通过敏感性分析来评估结果的稳定性和可靠性。结果IVW分析结果显示基因预测的BMI与肾癌的发病风险之间存在正相关性(OR:1.4425,95%CI:1.0821~1.9230,P=0.0125),与前列腺癌之间存在负相关性(OR:0.9926,95%CI:0.9887~0.9965,P=0.0002),而与膀胱癌之间没有因果关系(OR:1.0003,95%CI:0.9994~1.0011,P=0.5269)。敏感性分析和多效性分析显示本研究结果可靠,不存在异质性。结论基因预测的BMI是肾癌的危险因素,是前列腺癌的保护因素,与膀胱癌发病风险没有关联,这一发现可以为泌尿系统常见肿瘤预防策略的制定提供参考。Objective To explore the causal relationship between the body mass index(BMI)and the risk of urinary tumors using two-sample Mendelian randomization.Methods BMI data in IEU public database genome association and date of kidney cancer,prostate cancer,prostate cancer,bladder cancer were screened and analy through the inverse variance weighting method,MR-Egger regression analysis,weighted median analysis of two-sample mondel randomization method to evaluate the causal relationship between constitution index and urinary tumor.Finally,a sensitivity analysis was used to assess the stability and reliability of the results.Results Genetically-predicted BMI is positively related to the risk of kidney cancer(OR:1.4425,95%CI:1.0821-1.9230,P=0.0125),negatively related to the risk of prostate cancer(OR:0.9926,95%CI:0.9887-0.9965,P=0.0002),and had no causal relationship with the risk of bladder cancer(OR:1.0003,95%CI:0.9994-1.0011,P=0.5269).Sensitivity analysis and pleiotropy analyses showed that the results of this study were reliable and there was no heterogeneity.Conclusion Genetically-predicted BMI is a risk factor for renal cancer and a protective factor for prostate cancer.It is not associated with the risk of bladder cancer.This finding can provide reference for the potential risk of common urological tumors and the development of prevention strategies.

关 键 词：孟德尔随机化 身体质量指数 泌尿系肿瘤 因果推断 全基因组关联研究 肾癌 前列腺癌 膀胱癌 

分 类 号：R737.1[医药卫生—肿瘤]