Natural killer cell membrane doped supramolecular nanoplatform with immuno-modulatory functions for immuno-enhanced tumor phototherapy  

作　　者：Ying Gao Rong Zhou Qiwen Wang Shaolong Qi Yuanyuan Lv Shuang Liu Jie Shen Guocan Yu 

机构地区：[1]Institute of Pharmaceutics,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou 310058,China [2]Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province,School of Medicine,Hangzhou City University,Hangzhou 310015 China [3]Department of Cardiology,The First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China [4]MOE Key Laboratoryof Bioorganic Phosphorus Chemistry & Chemical Biology,Department of Chemistry,Tsinghua University,Beijing04,Chin [5]Emergency Department,State Key Laboratory of Complex Severe and Rare Diseases,Peking Union Medical College Hospital,Chinese Academy of Medical Science and Peking Union Medical College,Beijing 100730,China

出　　处：《Chinese Chemical Letters》2024年第10期205-212,共8页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.22175107,22305140,51603184,82270531);Zhejiang Provincial Natural Science Foundation of China(Nos.LY21E030002,LY22H020003);Scientific Research Foundation of Zhejiang University City College(No.J-202104);Hangzhou Science and Technology Bureau of China(No.202203B27)。

摘　　要：Photodynamic therapy(PDT)has garnered significant attention as a promising approach to cancer therapy,harnessing the combined benefits of localized light treatment and the accompanying host immune response.In this study,we engineered an immuno-enhanced PDT nanoplatform,denoted as HM@p-MOF(hybrid membrane@porphyrin-metal organic framework).The core porphyrin-MOF was cloaked with a hybrid membrane derived from B16F10 cancer cells and NK cells,resulting in enhanced stability.In both in vitro and in vivo experiments,our finding demonstrated that the hybrid membrane conferred dual targeting capabilities to the nanoplatform,leveraging the unique properties of the B16F10 membrane and NK membrane to augment immunogenic cell death(ICD)induced by photodynamic effects.Additionally,in conjunction with the immunomodulatory functions of the NK cell membrane,we observed an expansion of in situ immune infiltration leading to a systemic immune response.The HM@p-MOF nanoplatform exhibited the capacity to not only inhibit the growth of mouse melanoma but also suppress metastasis.This innovative HM@p-MOF nanoplatform present a viable strategy to enhance phototherapeutic efficacy for both localized and metastatic tumors.It provides a direction for the fabrication of biomimetic nanomedicines possessing immuno-modulatory function.

关 键 词：BIOMIMETIC Cell membrane Metal-organic framework PHOTOTHERAPY Tumor targeting 

分 类 号：R73-36[医药卫生—肿瘤] O641.3[医药卫生—临床医学] TB383.1[理学—物理化学]