White matter disease derived from vascular and demyelinating origins  

作　　者：Lin-Jie Zhang De-Cai Tian Li Yang Kaibin Shi Yaou Liu Yilong Wang Fu-Dong Shi 

机构地区：[1]Department of Neurology,Tianjin Medical University General Hospital,Tianjin,Tianjin,China [2]National Clinical Research Center for Neurological Diseases of China,Beijing Tiantan Hospital,Capital Medical University,Beijing,Beijing,China

出　　处：《Stroke & Vascular Neurology》2024年第4期344-350,共7页卒中与血管神经病学（英文）

基　　金：supported in part by the National Science Foundation of China(Grants 91642205 and 81830038);funds of Advanced Innovation Center for Human Brain Protection,Capital Medical University,Beijing,China;funded by Tianjin Key Medical Discipline(Specialty)Construction Project(TJYXZDXK-004A).

摘　　要：Damage or microstructural alterations of the white matter can cause dysfunction of the intrinsic neural networks in a condition termed as white matter disease(WMD).Frequently detected on brain computed tomography and magnetic resonance imaging scans,WMD is commonly presented in inflammatory demyelinating diseases like multiple sclerosis(MS)and vascular diseases such as cerebral small vessel disease(CSVD).Prevention of MS and CSVD progression requires early treatments with drastically different medications and approaches,as such,early and accurate diagnosis of WMD,derived from vascular or demyelinating etiologies,is of paramount importance.However,the clinical and imaging similarities between MS,especially during the early stage,and CSVD,pose a significant dilemma in differentiating these two conditions.In this review,we attempt to summarize and contrast the distinguishing features of MS and CSVD for aiding accurate diagnosis to ensure timely corresponding management in the early stages of MS and CSVD.

关 键 词：DIAGNOSIS MYELIN alterations 

分 类 号：R743[医药卫生—神经病学与精神病学]