Analgesic nanomedicines for the treatment of chronic pain  

作　　者：Hao Liu Hongjun Zhuang Ya Wang Yuen Yee Cheng Feixiang Chen Jian Chen Xinglei Song Run Zhang Yanyan Liu Wenbo Bu 

机构地区：[1]State Key Laboratory of Molecular Engineering of Polymers,Department of Materials Science,Fudan University,Shanghai,China [2]Department of Rehabilitation,Zhongshan Hospital,Fudan University,Shanghai,China [3]Central Laboratory,The First Affiliated Hospital of Xiamen University,Xiamen,China [4]Institute for Biomedical Materials&Devices(IBMD),Faculty of Science,The University of Technology Sydney,Sydney,New South Wales,Australia [5]Department of Anatomy and Physiology,Shanghai Jiao Tong University School of Medicine,Shanghai,China [6]Australian Institute for Bioengineering and Nanotechnology,The University of Queensland,Brisbane,Queensland,Australia

出　　处：《BMEMat(BioMedical Engineering Materials)》2024年第1期76-87,共12页生物医学工程材料（英文）

基　　金：National Natural Science Youth Fund,Grant/Award Number:82202326;Natural Science Foundation of Shanghai Municipality,Grant/Award Number:21ZR1405300;National Natural Science Foundation of China Youth Fund,Grant/Award Number:52322213;Shanghai Rising-Star Program,Grant/Award Number:21QA1400900;National Funds for General Projects,Grant/Award Number:52272269;Innovation Program of Shanghai Municipal Education Commission,Grant/Award Number:2023ZKZD01;Key Program of National Natural Science Foundation of China,Grant/Award Number:22235004。

摘　　要：Chronic pain is a major cause of suffering that often accompanies diseases and therapies,affecting approximately 20%of individuals at some point in their lives.However,current treatment modalities,such as anesthetic and antipyretic analgesics,have limitations in terms of efficacy and side effects.Nanomedical technology offers a promising avenue to overcome these challenges and introduce new therapeutic mechanisms.This article reviews the recent research on nanomedicine analgesics,integrating analyses of neuroplasticity changes in neurons and pathways related to the transition from acute to chronic pain.Furthermore,it explores potential future strategies using nanomaterials,aiming to provide a roadmap for new analgesic development and improved clinical pain management.By leveraging nanotechnology,these approaches hold the potential to revolutionize pain treatment by delivering targeted and effective relief while minimizing side effects.

关 键 词：ANALGESICS chronic pain local anesthetics NANOMEDICINE NEUROPLASTICITY 

分 类 号：R318[医药卫生—生物医学工程] R97[医药卫生—基础医学]