Recent advances in biomimetic aggregation-induced emission photosensitizers for photodynamic therapy and immunotherapy  

作　　者：Shuai Guo Hui Tang Yahui Zhang Zhouyu Wang Swee Ching Tan 

机构地区：[1]Department of Materials Science and Engineering,National University of Singapore,Singapore [2]Department of Chemistry,School of Science,Xihua University,Chengdu,China

出　　处：《BMEMat(BioMedical Engineering Materials)》2024年第3期74-91,共18页生物医学工程材料（英文）

基　　金：Ministry of Education Academic Research Fund Tier 1,Grant/Award Number:A-0009304-00-00;Sichuan Science and Technology Program,Grant/Award Number:2022NSFSC1269。

摘　　要：The development of novel photosensitizers(PSs)with aggregation-induced emission(AIE)properties has emerged as a crucial advancement in the field of photodynamic therapy(PDT).However,the versatile applications of AIE PSs are limited by low encapsulation efficiency and inadequate target tissue permeability.Biomimetic technology stands out as a promising strategy to overcome these challenges,aiming to enhance AIE PSs tumor penetration efficacy,and their association with antitumor immune responses.In this review,recent advancements in biomimetic AIE PSs for PDT and immunotherapy are summarized.We start with introducing strategies involving biomimetic AIE PSs based on cell membranes and extracellular vesicles for the combined application of PDT and immunotherapy.We then discuss the preparation of biomimetic AIE PSs nanoparticles.Finally,we briefly outline the challenges and prospects associated with biomimetic AIE PSs.

关 键 词：aggregation induced emission BIOMIMETIC IMMUNOTHERAPY photodynamic therapy PHOTOSENSITIZERS 

分 类 号：R392[医药卫生—免疫学]