遗传因素对抽动障碍患儿临床表现的影响  

Influence of genetic factors on the clinical presentation of children with Tic disorders

作　　者：胡誉宸 崔月华 王思蒙 韩斐[1] HU Yu-chen;CUI Yue-hua;WANG Si-meng;HAN Fei(China Academy of Chinese Medical Sciences,Guang'anmen Hospital,Beijing 100053,China)

机构地区：[1]中国中医科学院广安门医院,100053

出　　处：《临床精神医学杂志》2024年第5期359-363,共5页Journal of Clinical Psychiatry

基　　金：国家中医药管理局中医药循证能力建设项目(60102)。

摘　　要：目的:研究遗传因素对抽动障碍病情的影响,探索不同遗传印记、不同遗传代际下的抽动障碍发病特点。方法:选取200例非遗传抽动障碍患儿和100例遗传相关抽动障碍患儿进行病例对照研究,再将100例遗传相关抽动障碍患儿作为先证者开展家系研究,通过调查先证者一、二、三级亲属发病情况,统计分析不同遗传类型下抽动障碍的发病特点。结果:抽动障碍患者遗传组的严重程度显著高于非遗传组(P=0.042);遗传组患儿更容易合并其他精神心理疾病(P=0.012),特别是母系遗传(P=0.017);不同遗传代际下的抽动患儿病程不同。结论:遗传因素是抽动障碍的危险因素之一,遗传相关的抽动障碍患儿病情更严重;但母系遗传的抽动障碍患儿更易共患其他精神心理疾病。Objective:To compare the effect of the presence or absence of genetics on the condition of tic disorders and to explore the characteristics of tic disorders pathogenesis under different genetic imprints and different genetic generations.Method:A case-control study was conducted on 200 children with non-genetic tic disorders and 100 children with tic disorders associated with genetic imprinting,and then a family study was conducted on 100 children with tic disorders associated with genetic imprinting as the pre-documented patients.Results:The severity of tic disorders in the genetic group was significantly higher than that in the non-genetic group(P=0.042);children in the genetic group were more likely to be co-morbid with other psychosomatic disorders(P=0.012),especially in the maternal lineage(P=0.017);and the course of the disease was different for tic disorders in children under different genetic generations.Conclusion:Genetic factor is one of the risk factors for tic disorders,and children with genetically related tic disorders have more severe conditions;paternal inheritance is more common than maternal inheritance,but children with tic disorders inherited from the maternal line are more likely to be co-morbid with other psychiatric and psychological disorders.

关 键 词：抽动障碍 遗传 病例对照 家系研究 

分 类 号：R749.94[医药卫生—神经病学与精神病学]