Omega-3 in traditional medicine and its role in the treatment of Sickle Cell Disease complications  

作　　者：Tarimoboere Agbalalah Adekunle Babajide Rowaiye 

机构地区：[1]Department of Anatomy,Faculty of Basic Medical Sciences,Baze University,Jabi,900108,Abuja,Nigeria [2]Department of Medical Biotechnology,National Biotechnology Development Agency,Lugbe,900107,Abuja,Nigeria [3]Department of Agricultural Biotechnology,National Biotechnology Development Agency,Lugbe,900107,Abuja,Nigeria

出　　处：《Clinical Traditional Medicine and Pharmacology》2024年第4期76-82,共7页临床传统医学和药理学（英文）

摘　　要：Background:Sickle Cell Disease(SCD)presents a significant global health burden,characterised by inflammation and oxidative stress,contributing to its complex pathophysiology and substantial socioeconomic implications.Omega-3 has been shown to alleviate SCD and has been found to be richly available in traditional medicinal plants such as perilla seed,sea buckthorn and amaranth.Objective:This research highlights the potential of omega-3 fatty acid supplementation as a therapeutic intervention for SCD.Methods:We conducted an extensive search across databases such as PubMed,MEDLINE,and Google Scholar to gather pertinent articles that explore the effect of omega-3 fatty acid on inflammatory and oxidative stress markers in SCD.Keywords such as oxidative stress,and inflammation were also used in the search.Omega-3 fatty acids,particularly EPA and DHA,exhibit anti-inflammatory and antioxidant properties that hold promise in mitigating these pathological processes.Results:Clinical studies demonstrate reductions in pain episodes,hospitalisations,and oxidative stress markers with omega-3 supplementation,indicating its therapeutic efficacy.Conclusion:Further research is needed to determine optimal dosage,duration,and population-specific considerations.Comparative effectiveness studies and long-term safety assessments are essential for informing clinical practice.Integrating omega-3 supplementation into comprehensive treatment regimens alongside other modalities may offer a holistic approach to managing SCD.Overall,ongoing research efforts in omega-3 fatty acid supplementation offer hope for optimizing treatment strategies and improving outcomes for individuals affected by SCD.

关 键 词：Omega-3 fatty acid Sickle cell disease Oxidative stress INFLAMMATION Supplementation 

分 类 号：R394.2[医药卫生—医学遗传学]