Fusobacterium is toxic for head and neck squamous cell carcinoma and its presence may determine a better prognosis  

作　　者：Anjali Chander Jacopo Iacovacci Aize Pellon Radhika Kataria Anita Grigoriadis John Maher Cynthia Sears Gilad Bachrach Teresa Guerrero Urbano Mary Lei Imran Petkar Anthony Kong Tony Ng Ester Orlandi Nicola Alessandro Iacovelli Loris De Cecco Mara Serena Serafini David Moyes Tiziana Rancati Miguel Reis Ferreira 

机构地区：[1]Centre for Host-Microbiome Interactions,King’s College London,London,UK [2]Comprehensive Cancer Centre,King’s College London,London,UK [3]Department of Oncology,Guys and St Thomas NHS Foundation Trust,London,UK [4]Data Science Unit,Fondazione IRCCS Istituto Nazionale dei Tumori,Milan,Italy [5]Medicine Department,Johns Hopkins University School of Medicine,Baltimore,Maryland,USA [6]Institute of Biomedical and Oral Research,The Hebrew University-Hadassah School of Dental Medicine,Hadassah Ein Kerem Campus,Jerusalem,Israel [7]Dipartimento di scienze Clinico-Chirurgiche,Diagnostiche e Pediatriche,Universitàdegli studi di Pavia,Pavia,Italy [8]Radiation Oncology Department,Fondazione IRCCS Istituto Nazionale dei Tumori,Milan,Italy [9]Department of Medicine,Weill Cornell Medicine,New York,USA

出　　处：《Cancer Communications》2024年第8期879-883,共5页癌症通讯（英文）

基　　金：Wilson+Olegario:Philanthropy through Guys Cancer Charity(MRF)Guys Cancer Charity(MRF)Cancer Research UK through the City of London Cancer Centre(MRF)Fondazione Regionale per la Ricerca Biomedica,grant ID 2721017(JI).

摘　　要：Head and neck squamous cell carcinoma(HNSCC)is a devastating disease.Despite morbid treatment,5-year survival rates remain poor(28%-67%)[1].There is a significant knowledge gap regarding how the microbiota may impact HNSCC treatment efficacy[2].We used microbiome data from two independent cohorts to test and validate the hypothesis that oral bacteria are associated with HNSCC prognosis and in vitro models to investigate mechanistic underpinnings.Methods are detailed in Supplementary Materials.

关 键 词：PROGNOSIS SQUAMOUS carcinoma 

分 类 号：R73[医药卫生—肿瘤]