Impact of metallic nanoparticles on gut microbiota modulation in colorectal cancer:A review  

作　　者：Akash Kumar Jhilam Pramanik Kajol Batta Pooja Bamal Mukesh Gaur Sarvesh Rustagi Bhupendra G.Prajapati Sankha Bhattacharya 

机构地区：[1]Department of Food Technology,SRM University,Delhi NCR,Sonepat,India [2]MMICT&BM(Hotel Management),Maharishi Markandeshwar(Deemed to be University),Mullana,India [3]Department of Food Technology,William Carey University,Shillong,India [4]Department of Food Technology,ITM University,Gwalior,India [5]Department of Food Technology,Chaudhary Devi Lal University,Sirsa,India [6]Department of Food Technology,Guru Jambheshwar University of Science and Technology,Hisar,India [7]School of Applied and Life Sciences,Uttaranchal University,Dehradun,India [8]Shree S.K.Patel College of Pharmaceutical Education and Research,Ganpat University,Mehsana,India [9]Department of Pharmaceutics,School of Pharmacy&Technology Management,SVKM'S NMIMS Deemed‐to‐be University,Shirpur,Maharashtra,India

出　　处：《Cancer Innovation》2024年第6期11-28,共18页肿瘤学创新（英文）

摘　　要：Colorectal cancer(CRC)is the third most prevalent cancer.Ongoing research aims to uncover the causes of CRC,with a growing focus on the role of gut microbiota(GM)in carcinogenesis.The GM influences CRC development,progression,treatment efficacy,and therapeutic toxicities.For example,Fusobacterium nucleatum and Escherichia coli can regulate microbial gene expression through the incorporation of human small noncode RNA and potentially contribute to cancer progression.Metallic nanoparticles(MNPs)have both negative and positive impacts on GM,depending on their type.Several studies state that titanium dioxide may increase the diversity,richness,and abundance of probiotics bacteria,whereas other studies demonstrate dose‐dependent GM dysbiosis.The MNPs offer cytotoxicity through the modulation of MAPK signaling pathways,NF‐kB signaling pathways,PI3K/Akt signaling pathways,extrinsic signaling pathways,intrinsic apoptosis,and cell cycle arrest at G1,G2,or M phase.MNPs enhance drug delivery,enable targeted therapy,and may restore GM.However,there is a need to conduct well‐designed clinical trials to assess the toxicity,safety,and effectiveness of MNPs‐based CRC therapies.

关 键 词：APOPTOSIS CARCINOGENESIS DYSBIOSIS gastrointestinal microbiome titanium dioxide 

分 类 号：R735.37[医药卫生—肿瘤]