Understanding cachexia and its impact on lung cancer and beyond  

作　　者：Meiting Yue Zhen Qin Liang Hu Hongbin Ji 

机构地区：[1]State Key Laboratory of Cell Biology,Shanghai Institute of Biochemistry and Cell Biology,Center for Excellence in Molecular Cell Science,Chinese Academy of Sciences,Shanghai 200031,China [2]University of Chinese Academy of Sciences,Beijing 100049,China [3]School of Life Science and Technology,ShanghaiTech University,Shanghai 201210,China [4]School of Life Science,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,Hangzhou,Zhejiang 310024,China

出　　处：《Chinese Medical Journal Pulmonary and Critical Care Medicine》2024年第2期95-105,共11页呼吸与危重症医学（英文）

基　　金：supported by grants from the Key Research&Develop-ment Program of China(Nos.2022YFA1103900 and 2020YFA0803300 to H.J.);the National Natural Science Foundation of China(Nos.82341002 to H.J.,32293192 to H.J.,82030083 to H.J.,82173340 to L.H.,82273400 to Y.J.,and 32100593 to X.T.);the Basic Frontier Scientific Research Program of Chinese Academy of Science(No.ZDBS-LY-SM006 to H.J.).

摘　　要：Cancer cachexia is a multifactorial syndrome characterized by loss of body weight secondary to skeletal mus-cle atrophy and adipose tissue wasting.It not only has a significant impact on patients’quality of life but also reduces the effectiveness and tolerability of anticancer therapy,leading to poor clinical outcomes.Lung cancer is a prominent global health concern,and the prevalence of cachexia is high among patients with lung can-cer.In this review,we integrate findings from studies of lung cancer and other types of cancer to provide an overview of recent advances in cancer cachexia.Our focus includes topics such as the clinical criteria for di-agnosis and staging,the function and mechanism of selected mediators,and potential therapeutic strategies for clinical application.A comprehensive summary of current studies will improve our understanding of the mecha-nisms underlying cachexia and contribute to the identification of high-risk patients,the development of effective treatment strategies,and the design of appropriate therapeutic regimens for patients at different disease stages.

关 键 词：Cancer cachexia Staging systems MEDIATORS Signaling pathways Therapeutic strategies 

分 类 号：R73[医药卫生—肿瘤]