缺血修饰白蛋白、C反应蛋白、脂肪酶、淀粉酶水平与急性胰腺炎病情严重程度的相关性分析  

Correlation Analysis of Ischaemic Modified Albumin,C-reactive Protein,Lipase and Amylase Levels with the Severity of Acute Pancreatitis

作　　者：周瑞卿 卢慧娜 Zhou Ruiqing;Lu Huina(Department of Emergency Medicine,the First Affiliated Hospital of Baotou Medical College of Inner Mongolia University of Science and Technology,Baotou 014010,Inner Mongolia,China)

机构地区：[1]内蒙古科技大学包头医学院第一附属医院急诊医学科,内蒙古自治区包头014010

出　　处：《中国社区医师》2024年第28期77-79,共3页Chinese Community Doctors

基　　金：包头医学院青年骨干支持计划(编号:BYJJ-QNGG2022007)。

摘　　要：目的:分析缺血修饰白蛋白(IMA)、C反应蛋白(CRP)、脂肪酶、淀粉酶水平与急性胰腺炎(AP)病情严重程度的相关性。方法:选取2022年6月—2023年5月内蒙古科技大学包头医学院第一附属医院急诊医学科收治的120例AP患者作为AP组,根据病情严重程度分为轻度组、中度组、重度组,各40例;选取同期该院急诊医学科收治其他非缺血性腹痛患者30例作为对照组。检测患者血清IMA、CRP、脂肪酶及淀粉酶水平,分析IMA、CRP、脂肪酶、淀粉酶水平与AP病情严重程度的相关性。结果:AP组CRP、脂肪酶、淀粉酶、IMA水平均高于对照组(P<0.05)。CRP、脂肪酶、淀粉酶水平比较,轻度组<重度组<中度组,IMA水平比较,轻度组<中度组<重度组,差异有统计学意义(P<0.05)。CRP、淀粉酶、IMA水平与AP病情严重程度呈正相关(P<0.05);脂肪酶与AP病情严重程度关系不明显(P>0.05)。结论:血清IMA、CRP、脂肪酶、淀粉酶与AP发生发展密切相关,且IMA水平与AP病情严重程度相关,有望成为诊断AP的敏感生物标志物。Objective:To analyze the correlation between the levels of ischemic modified albumin(IMA),C-reactive protein(CRP),lipase and amylase and the severity of acute pancreatitis(AP).Methods:A total of one hundred and twenty AP patients admitted to the emergency medicine department of the First Affiliated Hospital of Baotou Medical College of Inner Mongolia University of Science and Technology from June 2022 to May 2023 were selected as AP group,and were divided into mild group,moderate group and severe group according to the severity of the disease,with forty cases each.A total of thirty patients with non ischemic abdominal pain were selected as the control group.Serum IMA,CRP,lipase and amylase levels were detected,and the correlation between IMA,CRP,lipase and amylase levels and the severity of AP was analyzed.Results:The levels of CRP,lipase,amylase and IMA in AP group were higher than those in control group(P<0.05);the levels of CRP,lipase and amylase were compared in mild group<severe group<moderate group;the levels of IMA were compared in mild group<moderate group<severe group,and the differences were statistically significant(P<0.05);the levels of CRP,amylase and IMA were positively correlated with the severity of AP(P<0.05);there was no significant relationship between lipase and the severity of AP(P>0.05).Conclusion:Serum IMA,CRP,lipase and amylase are closely related to the occurrence and development of AP,and IMA level is related to the severity of AP,which is expected to be a sensitive biomarker for the diagnosis of AP.

关 键 词：急性胰腺炎 缺血修饰白蛋白 C反应蛋白 脂肪酶 淀粉酶 

分 类 号：R576[医药卫生—消化系统]