Neuropeptide ACP is required for fat body lipid metabolism homeostasis in locusts  

作　　者：Li Hou Siyuan Guo Yuanyuan Wang Shaoye Liu Xianhui Wang 

机构地区：[1]State Key Laboratory of Integrated Management of Pest Insects and Rodents,Instute of Zoology,Chinese Academy of Sciences,Bejing,China [2]University of Chinese Academy of Sciences,Bejing,China

出　　处：《Insect Science》2024年第5期1453-1465,共13页昆虫科学（英文版）

基　　金：This study was supported by the National Key R&D Program of China no.2022YFD1400500;the National Natural Science Foundation of China(grant no.31930012 and 32070497);Youth Innovation Promotion Association CAS(no.2021079).

摘　　要：Fat body metabolism plays crucial roles in each aspect of insect life traits.Although neuropeptides have been documented to be one of the major neuroendocrinal regulators involved in fat body metabolism,the detailed regulatory mechanism is poorly explored.Here,we conducted comparative metabolome and transcriptome analyses of fat body between wide type(WT)and adipokinetic hormone/corazonin-related peptide(ACP)loss of function mutants of the migratory locust,Locusta migratoria.We found that knockout of ACP resulted in significantly reduced fat body triacylglycerol content but enhanced abundance of phospholipids,particularly phosphatidylcholine and phos-phatidylethanolamine.Additionally,the expression levels of genes involved in triacylglyc-erol and phospholipid synthesis and degradation were significantly altered in the fat body of ACP mutants.Moreover,female ACP mutants displayed much higher fecundity com-pared to WT females.These findings highlight the important role of neuropeptide ACP in fat body lipid metabolism homeostasis in locusts.

关 键 词：FECUNDITY lipid metabolism METABOLOME NEUROPEPTIDE transcriptome 

分 类 号：Q965[生物学—昆虫学]