Subconjunctival trypsin injection for anterior chamber fibrin exudates in eyes with globe rupture following vitrectomy  

作　　者：Shu-Wen Lu Hao-Yu Li Xin-Min Li Chao Ma Xian Li Qiu-Ming Hu 

机构地区：[1]Department of Ophthalmology,the First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,Henan Province,China [2]Department of Ophthalmology,the Second Xiangya Hospital,Central South University,Changsha 410021,Hunan Province,China [3]Hunan Clinical Research Centre of Ophthalmic Disease,Changsha 410021,Hunan Province,China [4]Department of Ophthalmology,the First Affiliated Hospital of Xinxiang Medical University,Xinxiang 453100,Henan Province,China [5]Department of Ophthalmology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan Province,China [6]School of Pharmacy and Optometry,Faculty of Biology,Medicine and Health,The University of Manchester,Manchester M139PL,United Kingdom [7]Department of Retina and Vitreous,Jingliang Eye Hospital,Guangxi Medical University,Nanning 530021,Guangxi Zhuang Autonomous Region,China

出　　处：《International Journal of Ophthalmology(English edition)》2024年第11期2037-2044,共8页国际眼科杂志（英文版）

基　　金：Supported by the Joint Construction Project of Henan Medical Science and Technology(No.LHGJ20220370);the Natural Science Foundation of Henan Province(No.232300420237).

摘　　要：AIM:To compare the safety and clinical outcomes of subconjunctival trypsin and dexamethasone(DEX)injections in the treatment of anterior chamber fibrin exudates in eyes with globe rupture following primary wound repair and vitrectomy.METHODS:A retrospective analysis included 42 males and 10 females(mean age 46.0±6.0y,range 34 to 58y)who underwent primary wound sutures and vitrectomy for globe rupture.Patients with pupil-covered fibrinous exudate or/and membrane in the anterior chamber were treated.On the first postoperative day,subconjunctival injections of either 5000 units(0.4 mL)of trypsin solution(n=25)or 0.5 mL(1 mg)DEX(n=27)were administered to accelerate exudate absorption.Efficacy was assessed by observing break time and partial absorption of the fibrin exudate membrane.Safety and comfort were evaluated by monitoring intraocular pressure(IOP),allergy,pain,and foreign body sensation.RESULTS:Both groups achieved 1/3 absorption of the anterior chamber fibrin exudate membrane,but the trypsin group exhibited shorter break time and partial absorption time compared to the DEX group(P<0.05).Trypsin treatment was also less irritating to patients.No adverse reactions were reported,and IOP remained stable.Visual acuity improved in both groups without statistical difference.CONCLUSION:Compared to DEX,trypsin demonstrates a shorter absorption time for the fibrin exudate membrane with a more comfortable process in treating pupil-covered fibrinous exudate or/and membrane after vitrectomy for globe rupture.

关 键 词：globe rupture VITRECTOMY exudative fibrin membrane TRYPSIN dexamethasone 

分 类 号：R779.6[医药卫生—眼科]