余甘子及其复配水提取物对功能性消化不良小鼠胃肠道激素和肠道微生物组的改善作用研究  

Improvement effect of Phyllum emblica extract and its compound aqueous extracts on gastrointestinal hormones and intestinal microbiota in mice with functional dyspepsia

作　　者：叶铸明 胡浩 林倩如 彭新安 蒋伊琪 刘果[2,3] 钟瑞敏 曹庸[2] YE Zhuming;HU Hao;LIN Qianru;PENG Xin’an;JIANG Yiqi;LIU Guo;ZHONG Ruimin;CAO Yong(Guangdong Provincial Key Laboratory of Utilization and Conservation of Food and Medicinal Resources in Northern Region,Shaoguan University,Shaoguan 512005;Guangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods,College of Food Sciences,South China Agricultural University,Guangzhou 510642;College of Light Industry and Food,Zhongkai University of Agriculture and Engineering,Guangzhou 510225)

机构地区：[1]韶关学院,广东省粤北食药资源利用与保护重点实验室,韶关512005 [2]华南农业大学食品学院,广东省功能食品活性物重点实验室,广州510642 [3]仲恺农业工程学院轻工食品学院,广州510225

出　　处：《中国食品添加剂》2024年第11期16-25,共10页China Food Additives

摘　　要：功能性消化不良是常见功能性胃肠道疾病之一,先前的研究中发现余甘子能够预防消化性溃疡和消化不良。本研究中,分别采用低、高剂量余甘子水提取物以及复配提取物连续三周灌胃造模功能性消化不良的balb/c雄性小鼠,观察小鼠各项生理指标及肠道菌群变化。结果发现,高剂量余甘子水提取物及复配水提取物相对于模型组,显著增加小鼠胃排空率及小肠推进率,提高胃动素及胃泌素含量,降低血清活性肠肽含量,提高胃蛋白酶活性。此外,肠道微生物组分析表明,余甘子水提取物通过提升有益菌丰度,抑制有害菌丰度的方式来调节肠道微生物组结构并恢复平衡。本研究证明了余甘子水提取物及其复配水提取物能改善功能性消化不良等症状,在维持消化道健康方面有一定的开发潜力。Functional dyspepsia(FD)is a common functional gastrointestinal disorder.Previous research has shown that Phyllum emblica has a preventive effect on peptic ulcers and dyspepsia.In this study,balb/c male mice with FD induced were treated with medium or high dose of Phyllum emblica aqueous extract and low or high concentration of compound aqueous extracts by three weeks of continuous gavage.Physiological indexes and intestinal flora were monitored throughout the observation period.The results showed,compared with the control group,high-dose Phyllum emblica aqueous extract group and compound aqueous extract group both significantly increased the gastric empty rate and intestinal propulsion rate,elevated serum level of motilin and gastrin level,decreased serum level of active intestinal peptide levels,and increased the activity of pepsin.Additionally,analysis of intestinal microbiome showed that the Phyllum emblica aqueous extract could regulate the intestinal microbiome structure and restore balance by promoting beneficial bacteria and suppressing harmful bacteria.This study demonstrated that the Phyllum emblica aqueous extract and its compound formulations could improve symptoms of functional dyspepsia and have potential in maintaining digestive tract health.

关 键 词：余甘子 功能性消化不良 胃肠道激素 肠道微生物组 

分 类 号：TS202.1[轻工技术与工程—食品科学]