Endometrial Cancer Research Based on Gut Microbiomics and Metabolomics:An Analysis of Correlation and Differences  

作　　者：Dan Xu Fengqin Xue Ruifang Zhai Sanyuan Zhang Zhe Wang Peiyue Yu 

机构地区：[1]Department of Gynaecology,The First People’s Hospital of Datong,Datong 037008,Shanxi,China [2]Department of Shanxi Medical University,Taiyuan 030012,Shanxi,China [3]Department of Gynaecology,The First Hospital of Shanxi Medical University,Taiyuan 030001,Shanxi,China

出　　处：《Biomedical and Environmental Sciences》2024年第10期1204-1207,共4页生物医学与环境科学（英文版）

基　　金：funded by the Fundamental Research Program of Shanxi Province(Grant number 202103021224394).

摘　　要：Endometrial cancer(EC)is a malignant tumour that occurs in the epithelial cells of the endometrium and represents one of the most common malignancies involving the female reproductive system,with endometrioid adenocarcinoma as the most common type.In recent years,with an increasingly aging society and the growing number of obese people,the incidence of EC is constantly rising,posing a serious threat to women’s health.Some studies have reported that the interruption of digestion and absorption caused by imbalance in intestinal microbiota may lead to conditions such as obesity,hypertension,diabetes,and hormone imbalance,which are all risk factors for EC.Meanwhile,intestinal bacteria produce a series of metabolites during colonization and reproduction,which can rapidly respond to changes in the microenvironment of the body.Changes in their types and quantities can serve as sensitive indicators of physiological and pathological changes in the body.Patients with EC often suffer from metabolic diseases,which can lead to metabolic disorders involving carbohydrates,fats,and amino acid in their bodies.

关 键 词：Metab CANCER QUANTITIES 

分 类 号：R737.33[医药卫生—肿瘤]